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Journal of Neurology and Neurorehabilitation Research | Volume 4
September 03-04, 2019 | London, UK
Spine and Spinal Disorders
4
th
International Conference on
J Neurol Neurorehabil Res, Volume 4
Preventing development of glucocorticoid-induced Osteoporosis by cod liver oil
Amr S Elbahnasawy
1,2
, E R Valeeva
1
, Eman M El-Sayed
2
and
N V Stepanova
1
1
Kazan Federal University, Russia
2
National Research Centre, Egypt
O
steoporosis is recognized by decreased bone density and
deterioration in bone structure, causing a decrease in
bone strength and an increase in bone fragility and fracture
problems. Glucocorticoids (GCs) are considered as one of
the main reasons of the secondary osteoporosis, and the
resulting fractures cause significant morbidity. fish oil can
decrease bone resorption, inhibit osteoclastogenesis, and
prevent bone resorption. The aim of the current work was
to evaluate the role of cod liver oil in preventing bone loss
and osteoporosis in glucocorticoid-treated rats. The fatty
acids profile of cod liver oil was analyzed, male rats were
fed balanced diet and subdivided into 3 groups, 1- normal
control, 2- prednisolone control, administrated prednisolone
(10 mg/kg po daily); 3- fish oil, administrated prednisolone +
cod liver oil (7% w/w).
Fatty Acid analyses showed that cod liver oil contained high
levels of long chain ω-3 polyunsaturated fatty acids (PUFAs),
eicosapentaenoic acid (EPA) and docosahexaenoic acid
(DHA). Supplementation with cod liver oil helped to improve
calcium levels in plasma and suppress oxidative stress and
inflammatory markers. Additionally, reduced bone resorption
as reflected from the decreased levels of C-terminal
telopeptide and showed significant improvement in bone
mineral density and normal histological results of bone cells
compared to normal and prednisolone control. Our study
indicated that feeding oil rich in PUFAs such as cod liver oil
was able to modulate the potential effect of prednisolone in
bon loss in rats. This may occur through some intracellular
pathways, involving the improvement of calcium absorption,
regulation of bone metabolism and the differentiation of the
osteoblast and osteoclast, suppression of oxidative stress and
modulation of inflammatory response. Therefore, cod liver
oil could be used as a natural approach to help in preventing
bone loss associated with glucocorticoid therapy.
e
:
amelbahnasavi@stud.kpfu.ru