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October 22-23, 2018 | Frankfurt, Germany
International Conference on
Robo t i c s a n d A u t oma t i o n
B iomater ial s and Nanomater ial s
Joint Event
&
Journal of Biomedical Research | Volume 29
Synthesis and characterization of polylactic acid electrospun membranes for controlled drug release
Jose A Gomez-Tejedor
Technical University of Valencia, Spain
José A Gómez-Tejedor, Robotics & Biomaterials 2018, Volume 29
DOI: 10.4066/biomedicalresearch-C6-017
In the present work, Polylactic Acid (PLLA) electrospun
membranes loaded with a drug have been developed and
designed with the purpose of being used for the regeneration
and healing of the skin. Tetracycline hydrochloride, a water-
soluble antibiotic, was introduced into the membrane. Due to
thehydrophobicity of PLLA, anemulsionwasmadebetween the
polymer solution and an aqueous phase to introduce the drug
into themembrane structure. Hyaluronic acidwas also included
intheaqueousphasetostudythestabilityoftheemulsionandits
possibleeffects on fibermorphology. Studieswere carriedout to
choose the operating conditions in the electrospinning process,
to optimize the amount of hyaluronic acid in the aqueous phase
and to observe the influence of the ratio of aqueous phase to
total emulsion. The results gave the electrospinning optimum
parameters of 7% of PLLA in the solution in chloroform/acetone
mixtures, 14 cm traveling distance of the jet, feeding rate of 1
mL/h and an applied voltage of 18 kV. Electrospun fibrils are
porous being the porosity dependent on the hyaluronic acid
content of the aqueous phase. In addition, an increase of the
pore area has been found by increasing the proportion of
aqueous phase. Thereafter, a study of drug release by means
of spectrophotometry showed low release yields (around 6%)
up to five-day delivery. On the other hand, a characterization
of the mechanical properties by tensile test gives the
membrane with 0.2% of hyaluronic acid as an optimum.
Speaker Biography
Jose A Gomez-Tejedor (Researcher ID: H-4614-2012, Orcid ID: 0000-0001-6854-0829,
Scopus ID: 55915419300) received his PhD in in theoretical physics in 1995 from the
Technical University of Valencia, Spain. In 1996 he joined the Technical University of
Valencia, where he is currently assistant professor of applied physics. His research has
focused in the synthesis, design and characterization of biomaterials for Tissue Engineering.
He has been working on the physical characterization of biomaterials using different
experimental techniques: Differential Scanning Calorimetry (DSC), Thermomechanical
Analysis (TMA), Dynamic Mechanical Analysis (DMA), Atomic Force Microscopy (AFM),
Scanning Electron Microscopy (SEM) AFM nano-indentation, etc. He has published more
than 50 papers in scientific journals and books that have been cited more than 550 times
(h-index = 12) and has made more than 50 contributions to international conferences.
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