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Journal of Public Health and Nutrition | Volume 2
July 05-06, 2019 | Paris, France
International Conference and Exhibition on
17
th
World Congress on
Probiotics, Nutrition and Functional Foods
Pediatrics and Nutrition
Joint Event
&
A study of dopamine D2 receptor Taq1 A alleles in children with attention deficit
hyperactivity disorder
Marwa Mohammed Moro
Ain Shams University, Egypt
Background:
Attention deficit hyperactivity disorder (ADHD)
is a common neuro-developmental disorder influenced
by many genes. The Dopamine receptor D2 (DRD2)
Taq1Apolymorphism affects the intracellular concentration
of the second messenger cyclic adenosinemonophosphate
(cAMP). This study aimed to assess the relationship between
Taq1 Apolymorphism and ADHD in a sample of Egyptian
children.
Methodology:
DRD2-Taq1Agenepolymorphismwasevaluated
in 100 participants, 50 ADHD patients and 50 controls of
healthy children with normal developmental and psychiatric
evaluation with comparable age and sex. The patients were
recruited from Psychiatric clinic, Faculty of Postgraduate
Studies for Childhood- Ain Shams University, Cairo, Egypt with
age ranged from 6 to 12 years. RD2-Taq 1A allele distribution
was investigated via polymerase chain reaction (PCR).
Results:
PhenotypedistributionsofA1alleleshowedstatistically
significant association with ADHD cases compared to controls
(p=0.037). A significant association was found betweenADHD
cases and heterozygous A1A2 genotype (p=0.047). Meanwhile,
ADHD cases showedstatistically significant lower distribution of
the homozygous A2A2 genotype (p=0.027).
Conclusion:
There was an evident association between
ADHD phenotype and (DRD2) Taq1Agene polymorphism, and
there was a heterozygous advantage regarding A1A2 allele
genotypeand ADHD cases.
Speaker Biography
Marwa Mohammed Moro graduated from faculty of medicine at Cairo
University, Egypt and had her master degree from the same university. She
has completed her PHD in January 2019 from Ain Shams University. She is
specialist of pediatrics in ministry of health hospitals, Egypt. She has some
publications that have been cited several times.
e:
sdr_loly5@yahoo.com