probiotics-pediatrics-congress-2019-accepted-abstracts

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Page 41
Journal of Public Health and Nutrition | Volume 2
July 05-06, 2019 | Paris, France
International Conference and Exhibition on
17th World Congress on
Probiotics, Nutrition and Functional Foods
Pediatrics and Nutrition
Joint Event
&
Prebiotic lactitol effects on gut microbiome in constipated old people
Daniele Scevola
University of Pavia, Italy
Trillions of bacteria -ten microbial cells for every cell of
our body-form a “metaorganism or metagenome” living
inside the gut( the 40%-55% of solid stool matter) that
influence many local and general vital functions like cancer,
aging process and related diseases. Microbial metabolite
choline is involved in colon cancer, nitric oxide affects host
longevity, short chain fatty acids (SCFAs) are beneficial in
constipation. We studied the action of disaccharide lactitol
compared to polyethylene glycol 3350 (PEG)on fecal content
of bacteria, short chain fatty acid (SCFAs) and enzymes in
old persones with constipation. Subjects aging >60 years
suffering from chronic idiopathic constipation, defined as
<3 spontaneous bowel movements per week, received 20g
of lactitol or 15g of PEG a day for four weeks. The study was
an open, randomized, parallel groups, third party (laboratory)
blinded trial. Compliance and clinical effects were similar and
all subjects with both treatments experienced an increased in
the number and a decreased in the consistency of stool per
day. Total fecalSCFAs, and particularly acetate and butyrate
concentrations increased with lactitol ands fell with PEG
(p<0.05). In lactitol group Bifidobacteria and Lactobacilli
counts correlate with total SCFAs (r=0.48,<0-05), acetate
(r=0.50,p<0.05), propionate (r=0.44, p<0-05), and respectively
with total SCFAs (r=0.44, p<0.05), butyrate (r=0.46, p<0.05),
isobutyrate (r=0.69,p<0.001), valerate ( r=0.53, p<0.001) and
isovalerate(r=0.58,p<0.005).InPEGgroupthethecorrelations
resulted significant between Enerobacteria and total
SCFAs, acetate, propionate, butyrate, isobutyrate, valerate,
isovalerate. The β-galactosidase vas significantly increased
by lactitol and decreased by PEG (p<0.05). Β-glucuronidase
fell with both treatments (p<0.05). pH from baseline value
of 7.5 ±0.7 turned toward acidity (6.6 ±0.8) with lactitol
and from 7.4 ± 0.7 toward alkalinity (7.7±0.5) with PEG. In
conclusion: lactitol and PEG both normalize the frequency of
evacuations but with different mechanisms. Lactitol works as
a prebiotic increasing stool SCFAs concentration, particularly
butyrate and acetate, while PEG, as pure osmotic laxative,
negatively interferes with colonic fermentation reducing
SCFAs production
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