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Page 59
November 13-14, 2017 Paris, France
5th International Conference on
PLASMA CHEMISTRY AND
PLASMA PROCESSING
Journal of Biotechnology and Phytochemistry
Volume 1, Issue 2 Plasma Chemistry 2017
Synthesis of hybrid, carbon-based magnetic,
hybrid nanoparticle systems using dense-
medium, atmospheric pressure plasma
approaches
Ferencz S Denes
University of Wisconsin Biological Systems Engineering, USA
Magnetic nanoparticles embedded in non-magnetic host
materials, including carbon structures are of special
interest due to the fact that embedding provides encapsulation
and prevents grain grow and agglomeration. A combination
of magnetic and electrical properties and the accessibility to
chemical modification of particles open up significant ways
for biotech applications. It has been suggested that the size
of the immunizing antigen particles controls their interaction
with specific Antigen Presenting Cells (APCs). Bacterial
sized (> 1µm) uptake is favored by macrophages, while viral-
sized (< 100 nm) are preferentially engulfed by DCs. Using
an original Dense Medium Plasma (DMP) technologies
and plasma reactors provided with iron electrodes, C and
C/N based uniformly sized (40-80nm) hybrid iron and
iron oxide containing magnetic nanoparticles (CMNP)
were synthesized by starting from benzene and acetonitrile.
Based on ESCA results, Fourier transform IR spectroscopy,
Raman spectroscopy, AFM and SEM it was shown that the
nanoparticles are composed of graphitic carbon or graphitic
carbon containing nitrogen atoms and small amounts of iron
and iron oxide. Thermal gravimetry/differential thermal
gravimetry analysis indicates that these particles are stable up
to temperatures as high as 600 oC. Ferromagnetic resonance
spectroscopy (FMR) and extended x-ray absorption fine
structure spectroscopy suggest that most of host structures
is related to metallic Fe. Magnetite and maghemite is also
present in the structure of the metallic particles. It was also
demonstrated that part of the nitrogen atoms included into
the acetonitrile-based structures are in the form of primary
amine functionalities. In this presentation based on “in
vitro” and “in vivo” experimental data, the potential use of
functionalized plasma-synthesized nanoparticles in future
immunotherapy applications is also discussed.
J Biot Phyt 2017