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July 05-06, 2019 | Paris, France
Pharmaceutics and Advanced Drug Delivery Systems
2
nd
International Conference and Exhibition on
Asian Journal of Biomedical and Pharmaceutical Sciences | ISSN:2249-622X | Volume 9
Water inclusion effect on starch 1500 as an excipient used in the production of the oral
solid dosage form
Saeid Rajabnezhad, Taravat Ghafourian, Ali Rajabi-Siahboomi, Shahrzad Missaghi, Majid Naderi
and
Ali
Nokhodchi
University of Sussex, UK
S
tarch 1500 is a well-known diluent, binder, disintegrant
and dissolution enhancer, which is widely used in the
formulation of the oral solid dosage forms. To validate the
proposed hypothesis that whether Starch 1500 preserves
the chemical hydrolysis of the moisture sensitive drugs,
the understanding the sorption-desorption behaviour of
this excipient is the first challenge. Water molecules when
interacting with most of the pharmaceutical excipients
and APIs localise within the crystalline part of the physical
structure. Specifically, for starch-based excipients, crystal
regions of the structure host the water molecules within the
double-stranded helices of the crystallite. DSC TGA, FTIR-ATR
and NIR techniques were adopted to determine the freezable
and nonfreezable bound water with starch 1500, both
qualitatively and quantitively. Among different mathematical
models, Young and Nelson model have not well practised
compared to the other available models, such as BET, GAB,
Oswin and Smith models. It was found out that Young and
Nelson model along with the GAB theory well carver the
sorption isotherms. The variable parameters obtained from
these two equations were compared and the monolayer
valuewas estimated. The amount ofmonolayer coveragewith
the assumption of the strength of the binding of the water
molecules on the first accumulated layer was correlated with
the total water content of the Starch 1500. Analysis of the
strength of the hydrogen bonds between Starch 1500 and the
water molecules, mobility and the availability of the reactive
water molecules to take part in chemical hydrolytic reactions
could be explained.
Speaker Biography
Saeid Rajabnezhad is a registered pharmacist since 2009. Beside working
as a community and hospital pharmacist, his main professional activities
are formulation development, quality control and production of oral solid
dosage forms as an industrial pharmacist. He has served various roles such
as R&D, QC and deputy of production manager in several pharmaceutical
companies. He was then joined the research group of Prof Ali Nokhodchi
at the University of Sussex, UK as a PhD researcher. His research is funded
through the University of Sussex and Colorcon Ltd. Saeid is in his final year
of PhD programme. He has published several articles in peer-reviewed
pharmacy journals in pharmaceutical technology, drug delivery and
nanoparticulate matters, powder engineering, characterisation as well as
analytical method development.
e:
s.rajabnezhad@sussex.ac.ukSaeid Rajabnezhad et al.
, Asian J Biomed Pharmaceut Sci, | ISSN: 2249-622X
Volume 9