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July 05-06, 2019 | Paris, France
Pharmaceutics and Advanced Drug Delivery Systems
2nd International Conference and Exhibition on
Asian Journal of Biomedical and Pharmaceutical Sciences | ISSN:2249-622X | Volume 9
Phyto-formulations for Matrix Metalloproteinases (MMPs): Novel targets in UV radi-
ation induced skin Carcinoma
Swarnlata Saraf
Pt Ravishankar Shukla University, India
The continuous exposure of skin to ultraviolet radiations
generates reactive oxygen species leading to photoaging
that causes degradation of dermal collagen and degeneration
of elastic fibers. These fibres provide mechanical strength
to the skin. In order to maintain the appearance of the skin,
a complete understanding of the mechanism behind skin
cellular degradation is desired, so that a better cosmetic
formulation can be formulated. The studies have been shown
that macrophages are crucially involved in skin Carcinoma
and express significantly higher levels of M1 (CD40, CD127)
and M2 (arginase I) markers as well as higher levels of
MMP-9, a pivotal enzyme in cancerous matrix remodeling
and cancerous invasion, than macrophages from the basal
cell carcinomas. These macrophages represent different
receptors like folic acid receptors which was exploited to
know the extent of efficacy for delivery of phyto-formulations
containing nanoparticles, transferosomes, liposomes etc. to
cure carcinoma. The flavanoidal rich natural bioactives have
been extensively incorporated in a suitable base and have
proven their potential as a topical photoprotectants but their
activity remained restricted due to poor solubility profile.
Now researchers are working to design the Novel Targeted
formulations to deliver these natural flavanoidal drugs to
improve its efficacy and ultimately skin properties. In current
years, the focus area of work is on some traditionally used
bioactive moieties as natural matrix metalloproteinases
inhibitors (MMPIs) and emphasized on more extensive and
specific studies, so that a good combination of natural as well
as synthetic MMPIs with the conventional drugs can be used
for treating UV radiations induced ailments.
Speaker Biography
SwarnlataSaraf isservingasaProfessoratPtRavishankarShuklaUniversity,
India since last 14 years. Her field of specialization is Pharmaceutics and
Research area of interest includes herbal formulations, drug delivery and
exploring targeting aspects of novel phyto-formulations. She has expertise
in developing phyto-formulations and passion in improving wellbeing of
the society. She gains this experience by continuous and consistent efforts
ofherwork incosmeticanddrugdelivery laboratories inthe institute.she is
associated withmany national apex bodies like NAAC, UGC, PCI, AICTE, and
CRS as member and as an expert in different committees. She also served
as an expert of grant evaluator of Israel Science Foundation. She Innovated
Technology for Value edition to existing herbs in Chhattisgarh & engaged
in promotional activities like Promotion of Janaushadi Kendra by dept. of
family welfare, Govt. of India, Regular interaction with pharmacists. She
is also Involved in awareness programmes through Shakti-Vigyan Bharati
relating to health & hygiene, Sustainable development and education for
women, Regular activities are organized for public awareness.
e:
Swarnlata Saraf, Asian J Biomed Pharmaceut Sci, | ISSN: 2249-622X
Volume 9