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Pharma Summit 2018 & Gastro Summit 2018 Asian Journal of Biomedical and Pharmaceutical Sciences | ISSN: 2249-622X | Volume 8
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Asian J Biomed Pharmaceut Sci 2018, Volume 8 | DOI: 10.4066/2249-622X-C5-015
THE EFFICACY OF SUPPLEMENTATION OF VITAMIN D3 ON THE ERADICATION
RATES OF CLARITHROMYCIN-BASED TRIPLE THERAPY FOR
HELICOBACTER PYLORI
INFECTION
Mohamed EL Shahawy
Al Azhar University, Egypt
Background/Aim:
Because of the emergence of antibiotic resistance and adverse drug reactions, the successful eradication
rates with the clarithromycin-based triple therapy are falling. The aim of this study was to assess the effect of supplementation
of 1,25-hydroxy vitamin D3 on the eradication rates of Clarithromycin-based triple therapy for Helicobacter pylori (H.pylori) in-
fection.
Methods:
This study included 150 patients diagnosed with H.pylori gastritis using magnifying narrow-band imaging endoscopy
(ME-NBI) supported by stool antigen test as a diagnostic gold standard. Serum 25-OH vitamin D levels was measured via Enzyme
Linked Immune Sorbent assay (ELISA) method before starting eradication therapy. Patients were divided into two groups: Pa-
tiesnts in group A (n=75) received amoxicillin, clarithromycin, and esomeperazol for 2 weeks. Patients in group B (n=75) received
1,25-hydroxy vitamin D3 for 4 weeks, in addition to amoxicillin, clarithromycin, and esomeperazol for 2 weeks. Stool antigen
test was performed 4 weeks after the end of therapy to check the eradication rates. The eradication rates were assessed using
per-protocol (PP) and intention-to-treat (ITT) analysis.
Results:
Our results revealed that, eradication was achieved in 46 of 62 patients (74.19%) by PP and 46 of 75 (61.33%) by ITT
analysis in group A while in group B , eradication was achieved in 60 of 68 patients (88.23%) by PP and 60 of 75 (80 %) by ITT
analysis . The eradication rates in Group B was significantly higher than that of Group A (p= 0.012 in ITT analysis and p=0.029 in
PP analysis). However, there were no statistically significant differences regarding serum 25-OH vitamin D level between these
2 groups and the mean 25-OH vitamin D level was 28.9±10.6 in group A and 28.3±9.8 in group B (p=0.268).
Conclusions:
Our results demonstrated that supplementing vitamin D3 to Clarithromycin-based Triple Therapy could provide
an additional advantage for achieving significantly higher eradication rates for H. pylori infection.
Keywords:
Vitamin D3, Magnifying narrow band, Helicobacter pylori eradication