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Pharma Summit 2018 & Gastro Summit 2018 Asian Journal of Biomedical and Pharmaceutical Sciences | ISSN: 2249-622X | Volume 8
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GASTROENTEROLOGY AND HEPATOLOGY
2
nd
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Asian J Biomed Pharmaceut Sci 2018, Volume 8 | DOI: 10.4066/2249-622X-C5-015
HELICOBACTER PYLORI
INFECTION IN CHILDREN WITH TYPE 1 DIABETES
MELLITUS
Mandana Rafeey
1
, Hassan Bazmamoun
2
and
Robabeh Ghergherehchi
1
1
Tabriz University of Medical Sciences, Iran
2
Hamadan University of Medical Sciences, Iran
Background:
Helicobacter pylori
infection is one of the most common chronic bacterial infections. There is challenge on the real
rate of prevalence of
H. pylori
in diabetic patients. This study was done to assess the prevalence of
H. pylori
infection in children
suffering from type 1 insulin-dependent diabetes mellitus.
Methods:
In this case-control study, 80 diabetic patients (as the target group) refer to the Endocrinology Clinic of Tabriz Edu-
cational and Treatment Center, Tabriz northwestern Iran and 80 non-diabetic patients (as the control group) from the group of
children referring to the GI Clinic of the same center were enrolled in 2012 and 2013. Then
H. pylori
infection was assessed in two
groups using measuring antibody (IgG) and stool antigen (HpSA).
Results:
H. pylori
infection tests were positive in 48 (60%) diabetic patients and in 32 (40%) in non-diabetic patients (P=0.030).
There was a meaningful correlation between the frequency of
H. pylori
and the longer the duration of diabetes (P<0.001). No cor-
relation was seen between
H. pylori
infection and other factors such as age of the patients (P=0.840), HbA1C level (P=0.312), age
at which diabetes was diagnosed (P=0.800), average daily dosage of insulin (P=0.232), and presence of GI symptoms (P=0.430).
Conclusions:
Type 1 diabetic children especially cases with the longer duration of diabetes, are at risk acquiring
H. pylori
infec-
tion. Therefore, screening of
H. pylori
infection is helpful on the follow up of these patients.
Keywords:
Children; Diabetes Mellitus;
Helicobacter pylori
s.