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N o v e m b e r 2 3 - 2 4 , 2 0 1 8 | B a n g k o k , T h a i l a n d
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Pharma Summit 2018 & Gastro Summit 2018 Asian Journal of Biomedical and Pharmaceutical Sciences | ISSN: 2249-622X | Volume 8
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GASTROENTEROLOGY AND HEPATOLOGY
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nd
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Asian J Biomed Pharmaceut Sci 2018, Volume 8 | DOI: 10.4066/2249-622X-C5-015
REGENERAGE SYSTEM: THERAPEUTIC EFFECTS OF COMBINATORIAL BIOLOGICS
(MRNA AND ALLOGENIC MSCS) WITH A SPINAL CORD STIMULATION SYSTEM ON A
PATIENT WITH SPINAL CORD SECTION
Joel I Osorio, Sergei Paylian
and
Ale Ismael
Gonzalez Cazares
Westhill University School of Medicine, Mexico
A
s it has been previously demonstrated that coelectroporation of
Xenopus laevis
frog oocytes with normal cells and cancer-
ous cell lines induces the expression of pluripotency markers and in experimental murine model studies that mRNA extract
(Bioquantine®) purified from intra and extra-oocyte liquid phases of electroporated oocytes) showed potential as a treatment for
a wide range of conditions, including Spinal Cord Injury (SCI) among others. The current study observed beneficial changes with
Bioquantine® administration in a patient with a severe SCI. Pluripotent stem cells have therapeutic and regenerative potential
in clinical situations CNS disorders even cancer. One method of reprogramming somatic cells into pluripotent stem cells is to
expose them to extracts prepared from
Xenopus laevis
oocytes. The positive human findings for spinal cord injury with the results
from previous animal studies with experimental models of traumatic brain injury and SCI respectively as our evidence and due to
ethical reasons, legal restrictions and a limited number of patients, we were able to treat only a very small number of patients, de-
ciding to include in our protocol the RestoreSensor SureScan to complete it. Based on the electrical stimulation for rehabilitation
and regeneration after spinal cord injury published by Hamid and MacEwan, we designed an improved delivery method for the
in-situ
application of MSCs and Bioquantine® in combination with the RestoreSensor® SureScan®. To the present day the patient
who suffered a complete section of spinal cord at T12-L1 shows an improvement in sensitivity, strength in striated muscle and
smooth muscle connection, 13 months after the first treatment and 6 months after the placement of RestoreSensor® at the level
of the lesion, showing an evident improvement on his therapy of physical rehabilitation (legs movement) on crawling forward and
backwards and standing on his feet for the first time and showing a progressively important functionality on both limbs.