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Note:
allied
academies
Joint Event on
S e p t e m b e r 1 0 - 1 1 , 2 0 1 8 | D u b l i n , I r e l a n d
TOXICOLOGY AND PHARMACOLOGY
PHARMACEUTICAL CHEMISTRY & DRUG DISCOVERY
&
Global Congress on
International Conference on
Pharma Chem Congress 2018 & Toxicology Congress 2018
Asian Journal of Biomedical and Pharmaceutical Sciences
|
Volume 8
Asian J Biomed Pharmaceut Sci 2018, Volume 8 | DOI: 10.4066/2249-622X-C2-006
ANTIBACTERIAL ACTIVITY AND PHYTOCHEMICAL ANALYSIS OF WILD
ORIGANUM SYRIACUM
ESSENTIAL OIL COMMONLY USED IN THE WEST
BANK
Mayadah Bashir Shehadeh
The University of Jordan, Jordan
O
riganum syriacum (O syriacum)
is a very popular edible and medicinal plant in the East Mediterranean countries. The current
study employed microwave-ultrasonic assisted hydro distillation (MAUHD) to produce EO from four wild
O syriacum
samples.
Gas chromatography coupled with mass spectrometer detector (GC/MS) was used for phytochemical analysis. Assessment of
their antibacterial and antioxidant potentials
in vitro
was carried out. Sesquiterpenes (24-39%) α-humulene and caryophellene
in addition to oxygenated monoterpenes (26-41%) thymol and carvacrol represent the bulk of phytochemicals detected by
GC-MS analysis. Thymol-rich EOs were found to be most effective against
Staphylococcus aureus
and methicillin-resistant
Staphylococcus aureus
(MRSA) (MIC 0.4 mg/mL). Carvacrol and α-humulene rich chemo type EO from Bethlehem, exhibited
the highest inhibitory effect of
Pseudomonas aeruginosa
(MIC of 1.6 mg/mL). Interestingly, γ-terpinene-rich EO from Jerusalem
and Bethlehem showed promising antibacterial properties against
Enterococcus faecium
and MRSA (MIC 100 and 200µg/mL
respectively). In conclusion, the current study supports the use of MAUHD as a time-saving, cost-effective, environment-friendly
method for production of high quality
O syriacum
EO for potential use in the treatment, prevention and adjuvant therapy against
bacterial infections without compromising the quantity.