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allied
academies
Joint Event on
S e p t e m b e r 1 0 - 1 1 , 2 0 1 8 | D u b l i n , I r e l a n d
TOXICOLOGY AND PHARMACOLOGY
PHARMACEUTICAL CHEMISTRY & DRUG DISCOVERY
&
Global Congress on
International Conference on
Pharma Chem Congress 2018 & Toxicology Congress 2018
Asian Journal of Biomedical and Pharmaceutical Sciences
|
Volume 8
Mahgoub M et al., Asian J Biomed Pharmaceut Sci 2018, Volume 8 | DOI: 10.4066/2249-622X-C2-006
BIOCHEMICAL AND BIOLOGICAL EFFECTS
OF IRISIN IN A MODEL OF DIABETES
MELLITUS
Mahgoub M
and
Ernest Adeghate
College of Medicine and Health Sciences-UAEU, UAE
D
iabetes mellitus (DM) is a highly prevalent health problem affecting
more than 425 million people worldwide. It is associated with several
detrimental complications such as neuropathy, nephropathy, retinopathy
and cardiovascular diseases. Irisin is a novel hormone that plays a role in
metabolism by stimulating the browning of white adipose tissue (WAT) into
beige adipose tissue which acquires properties that are like those of brown
adipose tissue (BAT). Several studies have attempted to characterize the
roles of irisin in DM and obesity; however, contradictory results have been
reported and physiological roles of irisin have been questioned by several
researchers. In our study, we investigated the role of irisin in controlling
glucose levels and insulin secretion in STZ-induced DM model and the
mechanismby which irisin exerts its beneficial effects both
in vivo
and
in vitro
,
using a variety of biochemical, morphological and cell biology techniques.
We showed that irisin did not cause any significant reduction in weight or
fasting blood glucose; however, it caused a significant glucose reduction 30
minutes after glucose challenge. Our data also showed that irisin co-localizes
with insulin in pancreatic β-cells in both normal and diabetic animals while
it co-localizes with glucagon only in diabetic animals. Moreover, irisin
was also detected in skeletal muscle, visceral and subcutaneous adipose
tissues. Irisin also reduced triglycerides and increased the level of high
density lipoprotein (HDL) and total protein. We also provided evidence that
irisin treatment can modulate the tissue level of different peptide hormones
such as insulin, glucagon, incretins and leptin. In addition, irisin possesses a
potent antioxidant activity and reversed oxidative stress induced by DM. Our
in vitro
investigations showed that irisin can stimulate the release of insulin
from pancreatic β-cells. Irisin could be a potential therapeutic agent in the
management of DM.
Mahgoub M is a Pharmacist who has been practicing
since graduation in 2009 until date. He has worked in
different settings like community pharmacy, hospital
pharmacy and ambulatory healthcare centre in United
Arab Emirates. In addition, his passion towards phar-
macological research has encouraged him in obtain-
ing his master’s degree in 2012 and PhD. His focus is
in diabetes mellitus pharmacology and particularly in
discovering new agents that can assist in controlling
hyperglycaemia and reversing complications associ-
ated with diabetes.
mahjoub_mohd@live.comBIOGRAPHY