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allied
academies
August 16-17, 2018 | Paris, France
Primary Healthcare
12
th
International Conference on
International Conference and Medicare Expo on
&
Pediatrics Health Care
Joint Event
Journal of Current Pediatric Research | Volume: 22
Introduction:
StudiescomparingtheDemyelinatingGBS(Dmy-
GBS) and axonal GBS (Ax-GBS) subtype in children are lacking.
Methods:
Inthishospitalbased,prospectiveandobservational
study, consecutive childrenwithGBSwere studied to compare
the clinical profile and outcome among the subtypes.
Results:
Among 9847 children admitted to the emergency,
95 had acute flaccid paralysis, 57 of whom had GBS.
Electrophysiologic studies were completed in 56, of whom
20 each had Dmy-GBS and Ax-GBS(19 motor axonal), 12 had
non-reactive nerves, and 5 unclassifiable findings. Mean age
of onset in Dmy-GBS was 55 months while Ax-GBS occurred
later at 84 months. More children in Ax-GBS group had
preceding gastroenteritis (4 vs 2), while Dmy-GBS had upper
respiratory infections (12 vs 7). Mean time from onset of
symptoms to hospital admission was more in Dmy-GBS 18
days to 8 days in Ax-GBS. Ataxia was only seen in Dmy-GBS
while wrist drop, foot drop and hyperreflexia were seen only
with Ax-GBS. Asymmetry of motor findings was more likely in
Ax-GBS(10vs4 P=0.048).Respiratorymuscle involvement (6 vs
3) and artificial ventilation (5 vs 2) was more in Ax-GBS. The
average duration of hospital stay was more in Ax-GBS 16 days
to 11 days in Dmy-GBS. Children with Ax-GBS less likely to be
non-ambulant at discharge (12 vs 6, p=0.036). Mean disability
scores at hospital discharge (4.9±1.2 vs 4±0.9, p=0.015)
and at last follow up (0.7±1.01 vs 0.05±0.2, p=0.016) were
higher in Ax-GBS. Children with Dmy-GBS were more likely to
achieve normalcy on follow up (19 vs 12, p=0.023). IVIg was
the treatment modality and was tolerated well with no side
effects reportedwithno relapseof symptoms after treatment.
Conclusion:
Axonal and demyelinating subtypes of GBS are
equally common in children of North India. Children with
axonal GBS have severe clinical course and more short term
morbidity and slower recovery.
e:
drpradeepgupta87@gmail.comHow different is demyelinating and axonal subtypes of Guillain-Barré syndrome (GBS) in children? A
study from tertiary care centre in Northern India
Pradeep Kumar Gupta, Naveen Sankhyan, Pratibha Singhi
and
Sunit Singhi
Siddhi Memorial Hospital, Bhaktapur, Nepal
Pediatrics & Primary HealthCare 2018, Volume 22
DOI: 10.4066/0971-9032-C1-003