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Journal of Current Pediatric Research | Volume: 23
March 14-15, 2019 | London, UK
International Conference on
Pediatrics & Neonatal Healthcare
Transfusion and Morbi-mortality factors: An observational descriptive retrospective Pediatric Cohort
study
Claudine Kumba, Fabiola Cresci, Camille Picard, Cécile Thiry, Souha Albinni
and
Gilles Orliaguet
Necker Sick Children’s University Hospital, Paris, France
Background:
Intraoperative and postoperative Morbi-mortality
factors are multiple in pediatric patients. Studies in pediatric
cardiac surgery and intensive care patients have identified
transfusion as one independent factor among others. There is
not a lot of data concerning transfusion relatedMorbi-mortality
in other pediatric patients fields like neurosurgery, abdominal
and orthopedic surgery. These were investigated.
Objectives:
To identify Morbi-mortality risk factors in
intraoperatively transfused and not transfused pediatric
patients in neurosurgery, abdominal and orthopedic surgery.
Design:
Retrospective observational descriptive pediatric
cohort study.
Setting:
Monocentric pediatric tertiary center, Necker Enfants
Malades University Hospital Paris, from 1 January 2014 to 17
Mai 2017.
Patients:
594 patients with mean age of 90.86 ± 71.80
months were included. Inclusion criteria were the presence
or the absence of transfusion in the intraoperative period in
neurosurgery, abdominal and orthopedic surgery patients.
Exclusion criterion was transfusion in the postoperative period
until discharge from hospital.
Main outcome measures:
Primary outcome was mortality
and secondary outcome was morbidity in transfused and
non-transfused patients. Mortality was assessed by deaths
occurring intraoperatively or postoperatively during the entire
hospitalization. Morbidity was assessed by intraoperative,
postoperative complications, repeat surgery, length of stay in
the intensive care unit, in the hospitalization ward, total length
of stay in hospital and length of mechanical ventilation.
Results:
Multivariate analysis revealed that ASA score was
the independent risk factor for mortality (odds ratio 28.78,
p-value<0.001). Transfusion (p-value<0.01), emergency
surgery (p-value<0.05), type of surgery (<0.01), age (<0.05)
and prematurity (<0.001) were independent risk factors for
morbidity.
Conclusions:
Patient outcome can be improved by applying
specific preventive measures on each risk factor.
Speaker Biography
ClaudineKumbagraduatedasaMedicalDoctor in2001andcompletedherspecialization
in Anesthesiology in 2006 at the Free University of Brussels (ULB, Université Libre de
Bruxelles). She has a Paediatric Anaesthesia specialisation graduation since 2010 from
the University of Aix-Marseille, Marseille, France. She has a Critical Care Medicine
specialisation graduation since 2014 from the University of Montpellier 1, Montpellier,
France. She is a paediatric anaesthesiologist in Necker Sick Children’s University
Hospital, in Paris, France. She has 12 publications and 17 citations. She is a member
of the European Society of Paediatric Anaesthesiology (ESPA), the French Society of
Anaesthesia and Critical Care (SFAR, Société Française d’Anesthésie-Réanimation) and
the French Association for Paediatric Anaesthesiolgists and Intensivists) (ADARPEF,
Association d’Anesthésistes et Réanimateurs Pédiatriques d’Expression Française) and
the Belgian Association for Paediatric Anaesthesiology (BAPA).
e:
Claudine.kumba@gmail.comNotes:
Claudine Kumba et al.
, Curr Pediatr Res, Volume 23
DOI: 10.4066/0971-9032-C1-012