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Journal of Clinical Pathology and Laboratory Medicine | Volume 3
July 05-06, 2019 | Paris, France
Pathology and Surgical Pathology
2
nd
International Conference on
Inter-observer variability in Gleason grading of prostate cancer biopsies
Emil Salmo
The Pennine Acute Hospitals, UK
G
leason score, which is an important histological
parameter in determining therapeutic decisions for
prostate cancer, has a high level of inter observer variability
amongst general and specialist urological pathologists.
A total of 96 prostate biopsies were reviewed and complete
agreementwas seen in seventy-twoper cent of cases following
central pathology review. Amongst caseswhichdemonstrated
Gleason score change, seventy-five per cent are downgraded
whereas twenty-five per cent are upgraded. Most of the
discrepancy involved pattern three and four, however, in
our series, there was evidence of over interpretation of
grade three and four and this might indicate the influence of
modification of Gleason scoring which was adopted in 2005
of the international society of urological pathology (ISUP).
Speaker Biography
Emil Salmo is currently working as a consultant histopathologist in Bolton
NHS Foundation Trust in Bolton, UK. His research areas of interest include
histopathology.
e:
emilsalmo@hotmail.com