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Journal of Clinical Pathology and Laboratory Medicine | Volume 3
July 05-06, 2019 | Paris, France
Pathology and Surgical Pathology
2
nd
International Conference on
Experimental facilities pave the rainbow access of the herbal melanin
Omar A Al-Tayib
King Saud University, Saudi Arabia
Backgrounds:
Melanin is a polymer found in most organisms
acts as natural biological, antioxidants factor by reducing
oxidative stress and inflammatory reaction of cells. It is
playing a vital role as an antioxidant agent as well as its
scavenging activities on free radicals. Also, melanin acts as
immunoprotective polymers preventing the tissues and cells
viaitsabsorbableactsagainstultravioletand/orotherradiation
and thus prevents any injured of the cells. Recently, melanin
has been extracted from the
Nigella sativa
seeds (NSM) and
thus researched for biomedical applications such as natural
protective agent with therapeutic effectiveness and targeted
as a natural therapeutic or drug delivery. This work presents
a general view of NSM extracts as a promising agent due to
its therapeutic outcomes using
in vivo
and
in vitro
methods.
Using of this type of melanin could play an important role
through the biological needs and/or could pave the way as an
active field of research including biochemistry, biomedical,
dermatological, cosmetic therapies and microbiological
points of view, as well as health care industry.
Methods:
In the current study, the latest published works
were studied to analyze the trend and pattern of the NSM
extracts and the impacts of machine learning methods.
Applications of histopathological methods and preclinical
imaging computerized techniques such as computed
tomography (CT) and nano CT Scans were also investigated
for the prediction and interpretation of the amelioration
effects of the NSM extracts via
in vivo
and
in vitro
clinical
models.
Results:
The results showed that NSM produced
significant pathological and morphological changes in
dose-and time-dependent manners in different organs
architecture during both
in vivo
and
in vitro
experiments.
In therapeutic development phases, it is well known the
advantages of computerized data outcomes and it can be
of importance related databases led to the success of the
whole pharmacotherapy modalities and/or provide to the
scientific field a new key transformative paradigms that can
revolutionize the treatment of diseases and hence medical
care.
Conclusion:
Experimental
in vivo
and
in vitro
researches are
valuable but also expensive and in some cases, researchers
may suffer from limitations. But a well understanding of the
therapeutic effects of this herbal extracts might pave the
way and thus provides a robust means a better designing
for much more effective natural medicinal agent or
therapeutic products and also grantees the patient safety.
e
:
oaltayib@ksu.edu.sa