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Journal of Clinical Pathology and Laboratory Medicine | Volume 3
July 05-06, 2019 | Paris, France
Pathology and Surgical Pathology
2
nd
International Conference on
Study the clinicopathological characteristics of primary malignancies of GIT in
patients ≤ 40 years of age and association of a positive family history
Qi Xue Ling
The Chinese University of Hong Kong, China
Background:
Gastrointestinal (GI) malignancies have been on
theriseintheyoung.Thisagegroupisassociatedwithadvanced
stages at presentation and aggressive histologies. Kashmir
has a considerable burden of GI cancers as compared to the
rest of the country with gastric, esophageal and colorectal
malignancies in the lead, but their comprehensive profile
in a young Kashmiri population has not been gauged so far.
Objective:
To study the clinicopathological characteristics of
primary malignancies of GIT in patients ≤ 40 years of age and
association of a positive family history.
Study design:
A 5 years observational study, divided into 1.5
years of prospective and 3.5 years of retrospective analysis,
extending from 2013-2017.
Methods:
The relevant details of cases fulfilling the inclusion
criteria were noted as per the proforma. Resection specimens
and biopsies were received and processed, archived samples
were retrieved and the cases analysed. Staging, wherever
applicable was done as per 8th AJCC guidelines. Frequency
distribution tables, bar diagrams and pie charts were used for
data presentation.
Results:
511/5676 cases (9%) of total registered primary
GI malignancies were present in our study group. The
leading sites were Anorectum (149, 29.1%), stomach (124,
24.3%), esophagus (113, 22.1%) and colon (104, 20.3%).
Adenocarcinoma was the leading histology (388/511,
75.9%), followed by squamous cell carcinoma (92/511, 18%),
neuroendocrine tumors (13, 2.5%) and 8 (1.6%) cases each
of GISTs and lymphomas. Mean duration of complaints was
6.4±7.2months. Majority cases had advanced stages (III-IV) at
presentation and aggressive histologies in the form of poorly
differentiated lesions and signet ring cell carcinomas. 44/511
(8.6%) of the total study cases had a documented positive
family history.
Conclusions:
Cases presented with nonspecific and protracted
symptomatology, advanced stages and poorly differentiated
lesions. Familial association could imply a hereditary
component or aggregation of shared environmental risk factors
or both.
e
:
xszqxl169@163.com