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academies
February 28-March 01, 2019 | Paris, France
Palliative Care, Obstetrics and Gynecology
Stroke and Clinical Trials
International Conference on
Joint Event on
International Conference on
&
Journal of Research and Reports in Gynecology and Obstetrics | Volume: 3
Etiologies, treatment options and fertility after recurrent miscarriages
Hasan Çilgin
Kafkas University, Turkey
Background:
Recurrent pregnancy loss (RPL)whichaffects 1–2%
of women is the loss of two or more consecutive pregnancies
before or during the 20th week of gestation. The aim of this
study is to determine the clinical characteristics, treatment
options and fertility after recurrent miscarriages.
Methods:
In this study, a total of 514 recurrentmiscarriage cases
that was diagnosed and treated between 2011 and 2017 were
retrospectively evaluated. All the related information including
the details of demographic characteristics, clinical symptoms
and findings, diagnostic tools used, treatment options, risk
factors for recurrent pregnancy loss, outcome of treatment
as well as couples underwent cytogenetic studies, radiologic
evaluation of the Müllerian system, and timed endometrial
biopsy were obtained fromhospital patient database and saved
in structured data entry forms designed for this purpose.
Results:
A total of 1680 deliveries with 532 RPL diagnoses
recorded and 514 of them were eligible for study and the RPL
was found3.2%.Agreatmajorityof thepatientswhoconstituted
the study group was between 25-34 years 62.4% (296/474)
At baseline, median female age was 34.1 years, waiting time
3 years (1–17), number of previous miscarriages 2 (2–9), 147
women (20.4%) had conceived at least once in ART or AIH
cycles. After a median follow-up of 33.7 (1.7–123.0) months,
5-year pregnancy and delivery rates were 86.1 and 64.5%.
Female age (29kg/m
2
), number of preceding miscarriages (> 4),
late miscarriages, preclinical losses and smoking revealed non-
significant negative trends. Mode of conception until baseline
(spontaneouslyorART/AIH) andclassification into idiopathicand
nonidiopathic RPL showed no prognostic relevance. Recurrent
pregnancy wastage was found to be associated with genetic
disorders in 25 couples, Müllerian anomalies in 15, endocrine
anomalies in 23, and negative findings in 37. The subsequent
reproductive performance of each group is reviewed
Conclusion:
As to give patients opportunities for as best as
possible chances to conceive a child greater emphasis should
be laid on diagnosis and appropriate treatment. Factors
associated with subfertility of couples have an important effect
on outcome.
Speaker Biography
Hasan Çılgın is from Turkey. He was graduated from Medicine Faculty of Istanbul
University in 2002. He completed his proficiency in obstetrics and gynecology
at Medicine Faculty of Fırat University in 2010 and have participated courses in
endoscopy, IVF and research methodology in various countries when he was a student
and an assistant at Medicine Faculties. After the training of assisted reproductive
technology in Istanbul University, he started pursuing his career at the department
of Reproductive Endocrinology and Infertility at Kafkas University since 2015. He has
been working at Medicine Faculty of Kafkas University since 2015.
e:
munzurluhasan@yahoo.comHasan Çılgın
, Res Rep Gynaecol Obstet, Volume 3
DOI: 10.4066/2591-7366-C1-002