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February 18-19, 2019 | Paris, France
Joint Event
Green Chemistry and Technology
8th World Congress on International Conference on
Organic and Inorganic Chemistry
Journal of Industrial and Environmental Chemistry| Volume: 3
Molecular hybridization: Novel methodology for the investigation of biological active heterocyclic moieties
Kamaldeep Paul
Thapar Institute of Engineering & Technology, India
Molecular hybridization is a strategy of rational design
of ligands or prototypes based on the recognition of
pharmacophoric sub-units in the molecular structure of two
or more known bioactive derivatives which, through the
adequate fusion of these sub-units, lead to the design of new
hybrid architectures. Hybrid drugs are basically designed to
counterbalance the known side effects associated with the
other hybrid part or to amplify its effect through action on
another bio target or to interact with multiple targets as one
single molecule lowering the risk of drug-drug interactions
and minimizing the drug resistance. Heterocyclic and fused
heterocyclic compounds for chemical classes have been
identified throughmolecular biology, molecularmodelling, drug
designing, empirical screening and rational drug development
for evaluation of anticancer agents during the past decades.
Purine, quinazoline, s-triazine, imidazopyrazine, benzimidazole
and naphthalimide aremost pervasive heterocyclic ring systems
found in nature and are pharmaceutically important classes of
compounds. Inmedicinal chemistry, thesemotifs have attracted
a great deal of research interest due to their preponderance
in pharmaceutically indispensable compounds. Thus, new
hybrids molecules by the combination of imidazopyrazine and
benzimidazole as well as naphthalimide and benzimidazole
have been synthesized. These hybrid molecules are then
evaluated in vitro for 60 human cancer cell lines for one dose
and five doses. The mechanism of possible activity of these
compounds is further evaluated with DNA for their interaction
studies using UV-visible and fluorescence spectroscopy.
Speaker Biography
Kamaldeep Paul has received his MSc degree from Department of Pharmaceutical
Sciences in 2000, and PhD in Synthetic Organic Chemistry from Department of
Chemistry, Guru Nanak Dev University, Amritsar in 2006. He is working as an
Associate Professor in School of Chemistry and Biochemistry, Thapar University,
Patiala, India. His area of research is Synthetic Organic and Medicinal Chemistry
where his research is broadly focused on multistep synthesis of heterocyclic
molecules and their in vitro evaluation for anticancer activity. He has published more
than 60 papers in reputed journals and has been serving as reviewers of repute.
e:
Kamaldeep Paul, J Ind Environ Chem 2019, Volume 3
DOI: 10.4066/2591-7331-C1-008