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academies
February 18-19, 2019 | Paris, France
Joint Event
Green Chemistry and Technology
8
th
World Congress on
International Conference on
Organic and Inorganic Chemistry
Journal of Industrial and Environmental Chemistry| Volume: 3
Targeting quadruplex nucleic acids: From chemical biology tools to drug prototypes
Marie-Paule Teulade-Fichou
CNRS, France
F
or many years our research efforts have been focused on
the design of small molecules for probing nucleic acid
structures. Our targets are more specifically tetra helical
secondary structures such as G-quadruplexes (G4) that can be
found in Guanine-rich regions. These structures are involved in
various genomic dysfunctions andmay ultimately cause genetic
instability related to cancer development. Our primary aim is to
provide chemical biology tools for a better understanding of the
roles of these structures. Our secondary aim is to evaluate the
anticancer therapeutic potential of quadruplex-targeted agents.
A large number of compounds have been developed for
targeting quadruplexes, but fewdisplay the criteria of selectivity
required for in-cell probing. We have contributed to develop
the bisquinolinium phenanthroline compounds (PhenDC) that
rank amongst the best G4 probes both in terms of affinity and
selectivity and which are usable in yeast and mammalian cells.
We will give a short overview of recent chemical developments
of these agents, of their use for probing quadruplex
formation in cells and of their anticancer drug properties.
Speaker Biography
Marie-Paule Teulade-Fichou has completed her first PhD (Pharmacology) in 1984 from
D Diderot University and her second PhD (Organic Chemistry) in 1986 from P&M Curie
University, Paris. She is the Director of the department “Chemistry Modelling and Imaging
for Biology” at the Institut Curie, Orsay, France. Currently she is working as CNRS research
Director and leader of the team “ Structure and Fluorescence Probes for Nucleic Acids”.
She has over 180 publications that have been cited over 7000 times and her publication
H-index is 45.
e:
mp.teulade-fichou@curie.frMarie-Paule Teulade-Fichou
, J Ind Environ Chem 2019, Volume 3
DOI: 10.4066/2591-7331-C1-008