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February 18-19, 2019 | Paris, France
Joint Event
Green Chemistry and Technology
8th World Congress on International Conference on
Organic and Inorganic Chemistry
Journal of Industrial and Environmental Chemistry| Volume: 3
Copper-catalyzed intra-molecular α-c‒h amination via ring-opening cyclization strategy to quinazolin-
4-ones: Development and application in rutaecarpine synthesis
Srilaxmi M Patel
Indian Institute of Technology, India
Acopper catalysed intramolecular α-C‒H amination has
been developed for the synthesis of quinazolin-4(3H)-
one derivatives from commercially available isatoic anhydride
besides primary and secondary benzyl amines via Ring-Opening
Cyclization (ROC) Strategy. This method shows good functional
group tolerance and allows access to a range of 2-aryl, 2-alkyl
and spiro quinazolinone derivatives and also 2-methyl and
2-aryl quinazolin-4(1H)-one derivative by C‒C and N‒C
bond cleavage in the progress of ROC strategy. It is the first
general method to construct the potentially useful 2-methyl
quinazolin-4(3H)-one by copper-catalyzed intramolecular C‒H
amination. And also, this ROC strategy has been successfully
applied to the synthesis of quinazolinone alkaloid rutaecarpine.
Speaker Biography
Srilaxmi M Patel was born in 1988 in Ameenpur, India. She obtained her BSc degree
from SLDC, Osmania University (OU), India in 2008 andMSc (Organic Chemistry) degree
from the MNR PG College, Osmania University (OU) in 2010, Later she worked as a
Lecturer in NTR Degree College for Women’s (June 2011 to July 2013) Mahaboob Nagar,
India. Then she joined the IIT Hyderabad in August 2013 as a junior research scholar.
e:
Srilaxmi M Patel, J Ind Environ Chem 2019, Volume 3
DOI: 10.4066/2591-7331-C1-009