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Page 36
allied
academies
February 18-19, 2019 | Paris, France
Joint Event
Green Chemistry and Technology
8
th
World Congress on
International Conference on
Organic and Inorganic Chemistry
Journal of Industrial and Environmental Chemistry| Volume: 3
Investigation of the anticancer activity of electron-deficient organometallic complexes
Maria Azmanova
University of Bradford, United Kingdom
R
uthenium and osmium complexes are considered as
an attractive alternative to platinum-based anticancer
drugs since the latter have major disadvantages such as
high toxicity, low selectivity and chemoresistance. We have
recently developed strong interest in electron-deficient
ruthenium and osmium complexes and investigated their
anticancer properties. The design of such molecules, with
possibilities of altering their activity by introducing different
ligands, is of a great importance, as well as unveiling their
mechanisms of action. Their cytotoxicity towards human
colon HCT116 p
53+/+
and HCT116 p
53-/-
cancer cell lines has
been investigated, including the effects these precious metal
complexes have on different genes involved in DNA damage
responses, cell cycle arrest, and apoptosis. Their mechanism
of action has been explored further by cell cycle analysis
and investigation of the oxidative stress they induce in cells.
e:
M.Azmanova@bradford.ac.ukJ Ind Environ Chem 2019, Volume 3
DOI: 10.4066/2591-7331-C1-009
Notes: