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LASER, OPTICS AND PHOTONICS
World Conference on
Obesity Summit 2018 & Diabetes Conference 2018 & Laser Photonics Conference 2018
Biomedical Research
|
ISSN: 0976-1683
|
Volume 29
Beatrice Nyanchama Kiage Mokua, Biomed Res 2018, Volume 29 | DOI: 10.4066/biomedicalresearch-C7-019
ANTI-DIABETIC AND ANTI-OBESITY
EFFICACY OF SELECTED KENYAN PLANT
EXTRACTS ON RATS FED A HIGH FAT AND
FRUCTOSE DIET
Beatrice Nyanchama Kiage Mokua
Jomokenyatta University of Agriculture and Technology, Kenya
P
lants are reported to have anti-diabetic and anti-obesity effects hence
can be explored in the treatment of these disorders. In this study, etha-
nolic and aqueous extracts were prepared from
Mangifera indica L, Loncho-
carpus eriocalyx
(Harms),
Urtica massaica Mildbr
.,
Schkuhria pinnata
(Lam)
and
Launaea cornuta
. Ethanolic extracts of all plants (1:100 dilutions),
in vitro
,
showed at least 29% inhibition of pancreatic lipase, but no effect on
α-gluco-
sidase
activity. The administration of the extracts for 74 days caused a signif-
icant reduction of liver triglycerides in male Wistar rats that had been fed on a
high fat and fructose diet (HFFD). There was also a tendency by the extracts
to prevent liver steatosis by reducing ALT and AST levels. Additionally, glyce-
mia and atherogenicity improved but hyperinsulinemia and insulin resistance
did not decrease. Conversely, there were inconsistencies on the effects of
the extracts on the evaluated parameters evaluated. However, Urtica mas-
saica was consistent in reducing glycaemia (fasting blood glucose, urinary
glucose, % HbA1c) and markers of hepatic steatosis (ALT and AST), which
were lower than the control. Hence, findings of this exploratory study imply
that these plants inhibit pancreatic lipase and therefore may be beneficial in
obesity treatment. Moreover, Urtica massaica could be further investigated
for anti-diabetic properties.
Keywords:
Diabetes, Plant extracts, Triglycerides, High fat high fructose, Liver
steatosis, Obesity.
Beatrice Nyanchama Kiage Mokua has completed her
PhD at the age of 37 years from Christian Albrechts Uni-
versity (CAU), Kiel, Germany. She is a lecturer at Jomo-
kenyatta University of agriculture and technology at the
department of food science and technology. She has
papers in reputed journals.
beatrice.kiage@jkuat.ac.keBIOGRAPHY