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O c t o b e r 1 5 - 1 6 , 2 0 1 8 | T o k y o , J a p a n
Obesity Congress 2018, Diabetes Congress 2018 & Vaccines Congress 2018 Biomedical Research | ISSN: 0976-1683| Volume 29
2nd WORLD OBESITY CONGRESS
2nd WORLD VACCINES AND IMMUNOLOGY CONGRESS
&
&
DIABETES AND ENDOCRINOLOGY
International Conference on
Joint Event on
OF EXCELLENCE
IN INTERNATIONAL
MEETINGS
YEARS
Hiroshi Bando, Biomed Res 2018, Volume 29 | DOI: 10.4066/biomedicalresearch-C5-013
CLINICAL EFFECT AND RESEARCH OF LOW
CARBOHYDRATE DIET (LCD) FOR OBESITY
AND DIABETES
Hiroshi Bando
Tokushima University, Japan
There have been various discussion concerning Calorie Restriction (CR)
and Low Carbohydrate Diet (LCD) for years. Author and colleagues have
treated lots of patients with metabolic syndrome such as obesity and type-
2 diabetes mellitus (T2DM) for LCD. We have investigated clinical research
related to CR and LCD, including ketone bodies (KB), Morbus (M) value, in-
sulinogenic index (IGI) in the field of diabetes and metabolic medicine. As
to clinical effect of LCD for weight reduction, we have data of 2699 cases.
Reduction ratio and percentage was that 10% and more than 10% in 25.6%,
5.0-9.9% in 32.0%, 2.5-4.9% in 21.2%, totally 78.8% in 2.5% and more than
2.5%. LCD showed clinical effect in 2 weeks. We have utilized specific proto-
col with the meal of CR and LCD, in which the content of carbohydrate is 60%
and 12%, respectively. Patients were provided CR on day 1, 2 and LCD on day
3-14. Several biomarkers related to glucose variability were investigated and
several studies were reported so far. They included daily profile of blood glu-
cose, average blood glucose, M value, triglyceride, HDL-C, LDL-C, RLP-C, ath-
erogenic index (T-C-HDL/HDL), TG/HDL value, uric acid, 3-hydroxybutyric acid
(3-OHBA), acetoacetic acid (AcAc), insulinogenic index (IGI) and response of
C-peptide for CR meal, and so on. Findings from the effect of LCD are as
follows: Subjects were patients with Type 2 diabetes mellitus (T2DM), ad-
mitted for 14 days and given diabetic evaluation protocol. Mean HbA1c was
8.0±1.7%. Median data day two vs. four were 208 vs. 147 mg/dL in average
glucose, 146 vs. 21 in M value and 123 vs. 94.5 mg/day in urinary C-peptide.
Consequently, LCD showed clinical effect of reducing weight and decreasing
blood glucose and M value. We will continue and develop clinical practice and
research concerning CD and LCD furthermore.
Hiroshi Bando is a Physician with specialties in dia-
betes, primary care medicine and life style-related
disease. He has over 2000 Japanese publication ar-
ticles, 30 books, 80 English medical publications, 800
lectures. He was the Chairman of Annual Congress of
8th Japanese Primary Care Association (2017) and
Editor of several medical journals on diabetes, endo-
crinology and metabolism. He has been the Chairman
of Shikoku Island division of Integrative Medicine Ja-
pan and was the chairman of annual Congress of 9th
Japanese Music Therapy Association (2009). He is
also a pianist and won the silver prize in 3rd European
International Piano Concours in Japan (EIPIC) (2012).
BIOGRAPHY