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O c t o b e r 1 5 - 1 6 , 2 0 1 8 | T o k y o , J a p a n
Obesity Congress 2018, Diabetes Congress 2018 & Vaccines Congress 2018 Biomedical Research | ISSN: 0976-1683| Volume 29
2nd WORLD OBESITY CONGRESS
2nd WORLD VACCINES AND IMMUNOLOGY CONGRESS
&
&
DIABETES AND ENDOCRINOLOGY
International Conference on
Joint Event on
OF EXCELLENCE
IN INTERNATIONAL
MEETINGS
YEARS
Gerardo Guillén et al., Biomed Res 2018, Volume 29 | DOI: 10.4066/biomedicalresearch-C5-013
VIRUS LIKE PARTICLES AND
NUCLEOPARTICLES AS A VACCINE
CANDIDATE
Gerardo Guillén, Aguilar JC, Hermida L, Gil L, Penton E
and Iglesias E
Center for Genetic Engineering and Biotechnology, Cuba
The existing vaccines are mainly limited to the microorganisms we can cul-
ture and produce and/or to those whose killing is mediated by humoral
response (antibody mediated). It has been more difficult to develop vaccines
capable to induce functional cellular response needed to prevent or cure
chronic diseases. New strategies should be considered in the improvement
of cell-based immune responses to prevent and control the infections and
eventually clear the virus. This work present preclinical and clinical results
with vaccine candidates against dengue virus, HBV and HIV based on virus
like particles (VLPs) and virus like nucleoparticles (VLNs) able to stimulate
mucosal as well as systemic immunity. Particles based on envelope or nucle-
ocapsid viral proteins induce a strong immune response after mucosal or sys-
temic administration in mice, non-human primates and humans. In addition,
the immune response obtained was biased in a Th1 sense.
Gerardo Guillén is a Biomedical Research Director at the
Center for Genetic Engineering and Biotechnology (CIGB)
in Havana, have more than 170 papers and 44 patents
published on vaccinology, biotechnology, infectious dis-
eases and pharmaceutical development. He has been
honored with 47 annual awards of Cuban Academy of
Science for scientific results, the Third World Academy
of Science award on Biology, the CJ Finlay Medal of the
Cuban State Council, awarded for upstanding results
on Science and the patent award of the World Office of
Intellectual Property. He is also the member of several
editorial boards. He is the member of the Scientific Ex-
pert Committees of the BioCubaFarma, the CIGB and the
Center for Tropical Medicine IPK.
BIOGRAPHY