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Insights Nutr Metab 2017
Volume 1 Issue 3
Nutrition World 2017
Page 71
September 11-12, 2017 Edinburgh, Scotland
15
th
World Congress on
Advances in Nutrition, Food Science & Technology
Insights Nutr Metab 2017
The Ghost Aim in Medical research -
Preventing
fattening/insulin
resistance/
overall inflammation
Mario Ciampolini
University of Florence, Italy
I
n the world, physicians more and more appreciate
findings on preprandial hunger arousal and less and
less deny their validity in my country (Tuscany). People
taking food after perceiving signals of hunger (Initial
Hunger Meal Pattern, IHMP) prevent fattening/insulin
resistance that causes an overall inflammation, diseases
like asthma, vascular and malignancy risks. I wonder why
scientists denied value to my endeavor. The division had
a start when I read the Handbook of Physiology of the
American Society for Physiology, in 1967. I was charged
with the treatment of malnutrition and diarrhea. I read the
handbook to become aware about mucosal digestion and
absorption. At that time, these points had to be diagnosed
to treat malnourished children. Before beginning any
research, a dynamic, reversible condition seemed instead
to operate in chronic diarrhea children and had to be
found. I read that 50% - 60% or more immune cells of
the human body reside in the mucosa of small intestine
(Mowat, 1987, 44; Brandtzaeg et al., 1989; Abrams,
1977). Bacteria grow in the small and large intestine in
dependence on nutrients, mainly those nutrients that
produce energy availability (sugars, carbohydrates,
amino-acids, fats (Hungate, 1967). Thus bacterial growth
is proportionate to positive energy balance. I studied
bacteria number on the intestinal mucosa in time after
last meal. A longer interval from the meal produced a
decrease in bacteria number. Thus I concluded that
meal absorption develops in a competition between
mucosa cells and bacteria (Ciampolini et al. 1996, 2000).
The conflictual nature of mucosal absorption has been
confirmed (Cooper, Siadaty, 2014; Mccoy, Köller, 2015).
I personally provided many demonstrations that current
meal pattern provides a lot of illnesses. I add here another
proof: The many successful cures of gastrointestinal
pathologies by IHMP suggest that the theory used for
recovery was objective. In this view, the question: ”what
food provokes cancer?” is absurd. Tumor heterogeneity
is a problem for cancer therapeutics. I am pleased by this
information. Malignancy needs to be prevented through a
better maintenance of immune system. Health follows the
relation between energy intake and expenditure. Both the
existence of hundreds or thousands of bacterial species
in intestine and the existence of a local huge immune
reaction in intestinal mucosa sustained the conflictual
view. Reading the Handbook isolated myself in a Medical
World that was unaware of microbiology. Physicians
saw improvements in the children I treated, but did not
understand the intestinal mechanisms that were far away
from their observation. They repeated: Ciampolini is alone
in his statements. Now, hundreds of printing houses, and
hundreds of scientific Journals ask me for submitting
articles. I am alone and cannot produce hundred articles
that are new and different each other. The growing number
of electronic Journals created a “Babel” condition that may
be useful for commercial exploitation (or for maintenance
of power in some editors) but not for the “ghost aim” of
improving awareness about the upsurge of malignant and
vascular risks, not to meet the expectation of one billion of
malnourished people.
Do we have to go on in the illusion of promoting knowledge
by printing ten similar articles instead of one? I would prefer
a grouping of Journals on basic assumptions: the study
of contagion, the study of energy balance, the study of
essential nutrients, the study of genetics. A confrontation
inside groups is necessary to decide either the opening of
new research fields or the fusion of similar Journals.
Publishing on Health requires an absence of conflicts
of interest. This becomes more and more difficult. I
was stopped in my institute just because I was unable
at constructing a profit from my findings. Individuals
devoid of conflicts of interest are precious and rare in a
complex world founded on the commerce of innovation
and research. Heads of Journals might join together in
an endeavor for the construction of a new order. Having
forwarded this claim for a shared action, I expect that
somebody will respond to my address to discuss chances.
The first step within the ghost aim should be the creation of
a consensus among scientists on the pathogenic principal
mechanism(s). The second step would be much easier:
teaching the consented mechanism to the population.
Other mechanisms might better function.
This small piece is intended to be published in many
Journals that requested a writing from mine. The piece
is sufficient to show a valid although intolerable situation.
mlciampolini@fastwebnet.it