nutrition-health-gastroenterologists-2019-posters

2 / 25

allied
academies
Page 33
Notes:
Journal of Nutrition and Human Health | Volume 3
May 23-24, 2019 | Vienna, Austria
Joint Event
2nd International Conference on Gastroenterology and Digestive Disorders
17th International Conference on Nutrition and Fitness
&
Inadequate timing of daily food intake may affect reproductive function in
post-adolescent female rats
Tomoko Fujiwara1 , Rieko Nakata2, Masanori Ono3, Michihiro Mieda3, Hitoshi Ando3, Takiko Daikoku3 and
Hiroshi Fujiwara3
1 Kyoto Notre Dame University, Japan
2 Nara Women's University, Japan
3 Kanazawa University, Japan
To investigate the effects of meal timing during circadian
cycle on the ovarian function, we performed animal
experiments using young female rats. Eight-week-old
female Wistar rats were classified into 3 groups: fed
during the daytime only (non-active phase), night-time
only (active phase), or control group I (without time or
calorie restriction) for 4 weeks, and daily body weight and
frequency of ovulation in each group were measured by a
weight scale and a vaginal smear, respectively. At the end
of the period of dietary restriction, ovaries were removed
and the numbers of growing follicles and corpora lutea
were evaluated based on hematoxylin-eosin-stained tissue
sections. In addition, 8-week-old female rats were fed only
during the night-time for 4 weeks under a 20% reduced
food supply of the control group II (without any restriction).
In the daytime-fed group, the frequency and number of
ovulations were significantly decreased compared with
those in the control group I. This group also showed a
reduced body weight gain concomitant with about 20% of
reduction in the daily food intake. In contrast, in the night-
time-fed group, evenwhen a 20% reduction of the daily food
intake was loaded, frequency of ovulation did not change as
compared with control group II. These findings indicate that
restricting food intake to the inactive phase impairs ovarian
function in post-adolescent female rats, proposing that the
timing of food intake during circadian cycle is an important
factor to interfering with the reproductive function.
Speaker Biography
Tomoko Fujiwara, is a Professor at Kyoto Notre Dame University,
graduated from Nara Women’s University in 1984 and Master Course,
Nara Women’s University in 1986. She was appointed as Professor
at Ashiya College in 2007. She obtained Doctor of Philosophy from
Nara Women’s University in 2009. In the meantime, she served as an
Editor-in-chief, Bulletin of Ashiya College in 2009-2015. From 2015, she
is Professor, Department of Home Science and Welfare, Kyoto Notre
Dame University, Kyoto, Japan. She has been studying the pathological
relationship between dietary habits and reproductive functions in
young women and published many papers such as “Fujiwara T Nakata R
(2010) Skipping breakfast is associated with reproductive dysfunction in
post-adolescent female college students. Appetite 55: 714-717.”
Hiroshi Fujiwara is a Professor and Chairman of Graduate School of
Medical Science, Kanazawa University, Japan
e: ;