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allied
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NEUROSCIENCE AND NEUROLOGICAL DISORDERS
PSYCHIATRY AND PSYCHOLOGICAL DISORDERS
&
International Conference on
International Conference on
J u n e 2 8 - 2 9 , 2 0 1 8 | D u b l i n , I r e l a n d
Journal of Neurology and Neurorehabilitation Research
|
Volume 3
Page 14
Note:
Joint Event on
T
he production of inflammatory proteins by the innate immune system is a
tightly orchestrated procedure that allows the body to efficiently respond
to exogenous and endogenous threats. In the talk the author will first discuss
accumulating evidence suggesting that disturbances in the inflammatory
response system not only provoke autoimmune disorders, but also can have
deleterious effects on neuronal function and mental health. As inflammation in
the brain is primarily mediated by microglia, the immune inflammatory cells of
the brain, there has been an expanding focus on themechanisms through which
these cells initiate and propagate neuroinflammation. Based on this evidence
theauthorwill debatenovel concepts about howmicroglia canenter persistently
active states upon their initial recognition of an environmental stressor and
are thereafter prone to elicit amplified and persistent inflammatory responses
following subsequent exposures to stressors. In view of the recent evidence
suggesting that primed microglia may be respond to environmental insults
through mechanisms involving the NLRP3 inflammasome; in the presentation
the author will then discuss new concepts supporting the activation of NLRP3
inflammasome mechanisms responsible for the generation of inflammatory
interleukins into functional forms that elicit several consequential effects in the
local neuronal environment. This evidence supports the principle that within
primed neuroimmune systems a lowered threshold for NLRP3 activation can
causepersistentneuroinflammationortheamplifiedproductionofinflammatory
cytokines. Collectively, the take home message of my presentation will provide
novel evidence suggesting that targeting the NLRP3 inflammasome complex
may represent an innovative approach to limit neuroinflammatory states in
psychiatric disorders.
Biography
Giulio Maria Pasinetti is The Saunders Family
Chair and Professor of Neurology, received anMD
from the Milan University School of Medicine and
a PhD from the University of Milan. He is currently
the Program Director of the NIH funded Mount
Sinai Centre for Molecular Integrative Neuroresil-
ience and the Chief of the Brain Institute Centre
of Excellence for Novel Approaches to Neurodi-
agnostics and Neurotherapeutics. He is also a
Professor of Psychiatry, of Neuroscience, and
of Geriatrics and Adult Development. He is the
recipient of several academic awards including
the prestigious Zenith and Temple awards from
the Alzheimer’s Association. Most recently, also
he was awarded with The Faculty Council Award’’
for academic excellence at Mount Sinai School
of Medicine and “The Charles Dana Alliance for
Brain Research Award” from Dana Foundation,
recognizing productivity and worldwide leader-
ship in his field of expertise, which further empha-
sizes his standing as an academic role model.
giulio.pasinetti@mssm.eduPRINCIPLES OF INFLAMMASOME
PRIMING AND INHIBITION:
IMPLICATIONS FOR PSYCHIATRIC
DISORDERS
Giulio Maria Pasinetti
Icahn School of Medicine
USA
Giulio Maria Pasinetti, J Neurol Neurorehabil Res 2018, Volume 3