neuroscience-2018-scientifictracks-abstracts

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Volume 2

June 11-13, 2018 | London, UK

Neurology and Neuroscience

International Conference on

Mircocircuitry for short-term memory and its relationship with Alzheimer’s disease

Hao Li

Capital Medical University, China

hort-TermMemory (STM) is the capacity to hold information

in the brain in an active, readily accessible state for a brief

period of time, typically from seconds to minutes. Its coding

mechanisms at the microcircuitry level remain a mystery.

Performing two-photon imaging on behaving mice to monitor

the activity of neuronalmicrocircuitry, we discovered a neuronal

subpopulation in the medial prefrontal cortex (mPFC) that

exhibited emergent properties in a context-dependent manner

underlying a STM-like behavior paradigm. These neuronal

subpopulations exclusively comprise excitatory neurons and

mainly represent a group of neurons with stronger functional

connections. In addition, we found the microcircuitry plasticity

wasmaintainedforminutesandwasabsentinananimalmodelof

Alzheimer’s disease (AD). Considering the toxicity of Aβ-soluble

oligomers is one of themajor causes of AD, in the future, we aim

to unveil whether and how Aβ-soluble oligomers will influence

the mircocircuitry plasticity for STM in AD animal models.

Speaker Biography

Hao Li graduated from Capital Medical University and got the M.D and Ph.D in 2017.

Currently, he is working as a neurosurgeon in the Department of Neurosurgery, Beijing

Tiantan Hospital, Capital Medical University. In the past five years, he have mainly

engaged in clinical and basic researches related to cerebral vascular diseases and

Alzheimer’s disease.