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May 16-17, 2019 | Prague, Czech Republic
2
nd
International Conference on
22
nd
International Conference on
Nanomaterials and Nanotechnology
Advanced Nanoscience and Nanotechnology
Joint Event
&
Journal of Materials Science and Nanotechnology | Volume 3
Mater Sci Nanotechnol, Volume 3
Investigating the role of gold nanoparticle shape and size in their toxicities to fungi
with a novel synthesis method
Kangze Liu
Technological University Dublin, Ireland
W
ith the flourishing development of nanotechnology,
abundant amount of nanomaterials have been
manufactured and applied in all sorts of areas in everyday life.
Among which, gold nanoparticles (GNPs) possesses a certain
proportion and very important status due to their fascinating
properties like quantum size effects and wide applications
in the fields of surface enhanced Raman scattering (SERS),
chemical and biological sensing, biomedicine and so on. With
such high usage in daily and industrial life, the release of
GNPs into the environment is increasing in great quantities.
Thus, attentions have been drawn to the effects of GNPs to
the environment, especially the effects on living organisms,
and ultimately the effects on human bodies and health.
Unfortunately, the characteristics of the toxicology of GNPs
on living organisms are still not fully understood up till now.
In our study, a novel synthesis method of shape and size
controllable GNPs has been developed. And with such
method, gold nanoflowers sized from as small as less than
1nm to ~60nm; along with mixtures of gold nanospheres
and gold nanoplates from ~5nm to large aggregates of
~400nm has been synthesized to investigate the relationship
of GNPs’ toxicities with their size and shape. Fungi has been
chosen for toxicity assessment due to their important role
as decomposers in the ecosystem, which enables fungi to
directly interact with the ecosystem and control its health
condition. In our study,
Aspergillus niger, Mucor hiemalis,
and Penicillium chrysogenum
were selected and exposed to
the GNPs with designed size and shape and incubated for 48
hours before survival rates were examined and compared.
Our results indicated that fungi species caused the largest
variety of the tolerance to GNPs. Meanwhile, larger and non-
spherical GNPs held higher toxicities.
Speaker Biography
Kangze Liu is currently a PhD student in Technological University Dublin,
Ireland. She graduated from the Department of Hydraulic Engineering in
Tsinghua University, China in 2015 and got BE in hydraulic engineering. Her
current research focuses on the novel synthesis methods, characteristics
and applications of gold nanoparticles. Her research topics include but
not limited to: Establishment and evaluation of nanotest as a detection
method of human fungal infections; evaluation of cold atmospheric
plasma (CAP) for brain cancer treatment; establishment of a bottom-up
in situ synthesis method of GNPs using phosphates and evaluation of
its toxicity; establishment and evaluation of digital nanotest as a smart
microbial detection system for water monitoring. Up till now, she has 3
papers published in international peer-reviewed journals, and 1 published
book chapter. She is also a reviewer and has reviewed 8 papers for journals
on MDPI.
e:
kangze.liu@dit.ie