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Journal of Materials Science and Nanotechnology | Volume 2
October 29-30, 2018 | London, UK
Nanomaterials and Nanotechnology
International Conference on
Paclitaxel-loaded magnetic nanoparticles as a targeted drug delivery system
Yu-Ming Wang
Chang Gung University, Taiwan
P
aclitaxel, a microtubule-stabilizing antineoplastic cytotoxic
drug, inhibits invasiveness of several cell types. In this work,
an anticancer drug delivery system that combines magnetic
nanoparticles with a layer-by-layers system will be proposed.
The monodisperse superparamagnetic iron oxide (SPION)
was prepared by thermal decomposition. The surface of the
iron oxide particles was functionalized with a carboxyl group.
Functionalized Fe
3
O
4
@TMS-EDTA combined with layer-by-
layers system: Poly(l-lysine)/poly(l-glutamic acid) (PLL/PGA).
Next, biotinylated paclitaxel is combined with Fe
3
O
4
@TMS-
EDTA/PLL/PGA system. The system of Fe
3
O
4
@TMS-EDTA/PLL/
PGA/biotinylated paclitaxel has a strong antiangiogenic activity,
a property that might contribute to its antineoplastic activity
in
vivo.
Speaker Biography
Yu-Ming Wang is currently pursuing his master’s in graduate Institute of Biochemical
and Biomedical Engineering of Chang Gung University, Taiwan.
e:
yuming5331@gmail.com