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academies
Journal of Materials Science and Nanotechnology | Volume 2
October 29-30, 2018 | London, UK
Nanomaterials and Nanotechnology
International Conference on
Synthesis of acidity triggered cisplatin encapsulated slow release zinc oxide targeted drug delivery
nano composite for cancer treatement
Rajapakshe
University of Peradeniya, Sri Lanka
C
isplatin is a frequently used anticancer drug with a cis
configuration that facilitates the covalently binding of the
coordination complex to DNA strands and thus crosslinking
the DNA strands triggering the cells to die in a programmed
manner. However, cisplatin is associated with several side
effects which can be either reduced or overcome if cisplatin
could be encapsulated in a suitable host material and directed
towards cancer cells in a targeted manner. To achieve these
targets, we have prepared porous nanoparticles of zinc oxide
(ZnO) and encapsulated cisplatin in them and studied their
release kinetics in buffered solutions of defined pH values.
Since cancerous cells are more acidic compared to normal cells
and that ZnO is stable in neutral pH media while decompose
slowly in low acidic conditions, it can be a highly suitable host
to release drug slowly only at the vicinity of the cancer cells.
We developed a novel surfactant-assistedmethod to synthesize
porous nanoparticles of ZnO. The encapsulation of cisplatin was
characterised by XRF, SEM, FT-IR and XRD studies. The release
kinetics of cisplatin at different pH values was investigated by
measuring the amount of Pt released as a function of time
using ICP-AES. It shows the release of cisplatin is pH dependent
and there is hardly any release of cisplatin at neutral and
basic pH values. As such, at physiological pH of blood and
that of healthy cells cisplatin is not released while at mildly
acidic pH values of cancer cells cisplatin is slowly released.
e:
sandil.rs89@gmail.com