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O c t o b e r 1 9 - 2 0 , 2 0 1 8 | T o k y o , J a p a n
Materials Summit 2018 & Separation Summit 2018 Materials Science and Nanotechnology | Volume 2
ADVANCED MATERIALS AND POLYMER SCIENCE
SEPARATION TECHNIQUES
&
International Conference on
International Conference and Expo on
Joint Event on
OF EXCELLENCE
IN INTERNATIONAL
MEETINGS
YEARS
Marine Michel et al., Mater Sci Nanotechnol 2018, Volume 2
ENANTIOSELECTIVE POLYMERIC
COMPOSITE MEMBRANE FOR CHIRAL
SEPARATION OF RACEMIC MIXTURES
Marine Michel1,2, Bradley P Ladewig1 and Matthew R Hill2
1Chemical Engineering, Imperial College London, UK
2CSIRO Manufacturing, Australia
Many pharmaceuticals exist as a mixture of two enantiomers (optical
isomers). Chiral separation of enantiomers is attracting interest as
the demand for enantiopure pharmaceuticals is growing dramatically. The
biological response such as toxicological behavior, therapeutic activity,
or immune response is strongly dependent on the configuration of a
given molecule, including its chirality and two enantiomers can display a
different optical activity. However as they have the same physico-chemical
properties, their separation is a challenging task but is crucial as the incorrect
enantiomer of the drug can offer no curative effect or even be detrimental.
Optical resolution of racemic mixtures has been broadly studied by various
methods including chromatography, diastereomer formation and preferential
crystallization. Among these techniques, membrane processes are seen as
serious alternatives to established chiral separation technologies, especially
since they have lower energy costs, are continuous, eco- friendly, economical
andareeasy toscaleup. Inoptical resolution, themembraneactsasaselective
barrier and transports one of the paired enantiomers preferentially because
of a stereo-specific interaction between enantiomers and chiral recognition
sites present in the membrane. The chiral recognition can be introduced in
the membrane by various means such as incorporation of chiral selectors,
grafting of chiral side chains in the polymer, chiral backbone polymer etc.
Most studies of chiral separation membranes have been performed using
dialysis method, where the driving force for the permeation and separation of
chiral chemicals is the concentration difference between feed and permeate.
With this method the concentration of the final product is more dilute than
that of the feed solution, and permeation is extremely slow. Ultrafiltration or
nanofiltration chiral separation membranes, using a pressure-driven force
as the driving force could be the answer to these disadvantages. This work
focuses on membrane-based enantioseparation technique, performed in
pressure driven separation mode, which has the potential for large-scale
production of enantiopure compounds and could pave the way for many more
commercial applications satisfying the considerable demand for large-scale
chiral separation techniques.
Marine Michel is a Chemical Engineer (ENSIACET,
France, 2015) and graduated with a MSc in Chem-
ical Engineering from Imperial College, London, UK
(2015). She is now pursuing a PhD degree in mem-
brane separation process at Imperial College London,
UK and is a member of the Barrer Center.
BIOGRAPHY