materials-summit-separation-summit-2018-posters

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O c t o b e r 1 9 - 2 0 , 2 0 1 8 | T o k y o , J a p a n

Materials Summit 2018 & Separation Summit 2018

Materials Science and Nanotechnology

Volume 2

ADVANCED MATERIALS AND POLYMER SCIENCE

SEPARATION TECHNIQUES

International Conference on

International Conference and Expo on

Joint Event on

OF EXCELLENCE

IN INTERNATIONAL

MEETINGS

YEARS

Mater Sci Nanotechnol 2018, Volume 2

PH-SENSITIVE AMPHIPHILIC POLYPEPTIDE PRODRUG FOR NIR IMAGING-

GUIDED COMBINED PHOTODYNAMIC THERAPY AND CHEMOTHERAPY

Zheng Ruan, Pan Yuan

and

Lifeng Yan

University of Science and Technology of China, China

hotodynamic therapy (PDT) is a promising clinical modality for the treatment of tumors and non-malignant nidus. A 4,4-difluoro-

4-bora-3a, 4a-diaza-sindacene (BODIPY) core-based photosensitizer (PS) has many of the ideal characteristics of a PDT agent,

such as a high extinction coefficient, resistance to photobleaching, and high ratios of light–dark toxicity which could also be

recognized as dye for bioimaging. However, the BODIPY mentioned above cannot be dispersed in aqueous solution since it is

hydrophobic, and therefore needs a BODIPY-carrier so that the PDT agent can be delivered and then released in the areas of tumors

to kill cells. And few researchers have combined chemotherapy using DOX with a photosensitizer which shows great lethality to

cancer cells like HepG2 and eminent bioimaging ability. Owing to the significant acidic microenvironments of tumor tissues and

low pH (~5.0) inside cancer cells, we have innovatively tried to synthesize hydrazine-based pH-sensitive peptide within PEG shells

and entrapped by the novel NIR-BODIPY photosensitizer using DOX for anticancer curing. The integration of chemotherapy and PDT

has met the rising necessity of combination for clinical diagnosis. All the polymeric micelles are of suitable size for the EPR effect

and can be easily disassembled in an acidic microenvironment to release the DOX or BODIPY for cancer treatment. The polypeptide

itself shows great biocompatibility to cells, while severe damage to HepG2 cancer cells was caused by micelles with BODIPY and

DOX which have also shown well NIR-imaging ability. All those advantages above mean that dual-agent pH-sensitive polypeptides

may be promisingly applied in future medical cures in a combination of PDT and chemotherapy.