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Mater Sci Nanotechnol 2017
Volume 1 Issue 3
Magnetic Materials 2017
Page 78
October 09-10, 2017 London, UK
International Conference on
New frontiers of magnetic materials for
regenerative medicine
Ugo D'Amora, Teresa Russo, Antonio Gloria, Roberto De Santis
and
Luigi
Ambrosio
Institute of Polymers, Composites and Biomaterials, Italy
O
ver the past years, the fundamentals of magnetism
and magnetic materials have been widely employed in
medicine (such as, indrug and gene delivery andhyperthermia
treatment of tumors). The possibility to apply these principles
to tissue engineering has opened an interesting wide
research area of interest. Tissue engineering aims to develop
multi-disciplinary approaches for the repair/regeneration
of damaged tissues. The main goal is to reconstruct tissues
using three-dimensional biodegradable and biomimetic
"scaffolds" as a template for cell growth and extracellular
matrix deposition. In the design of scaffolds with magnetic
properties, the main driving idea was to obtain structures
able to be manipulated through magnetic force gradients
attracting bio-aggregates, linked to magnetic carriers
(i.e. vascular endothelial growth factors) and stimulating
angiogenesis and bone regeneration. Furthermore, they can
also be used as hyperthermia agents for delivering thermal
energy to targeted bodies. Great attention has been focused on
the manufacturing process, the material and scaffold features
including morphological, chemical-physical, mechanical and
mass transport performances through a suitable topological
optimization. In particular, fully biodegradable and magnetic
nanocomposite scaffolds were produced through additive
manufacturing. The properties of the scaffolds were assessed
through experimental/theoretical
in vitro
investigations and
in
vivo
tests. Morphological studies were performed with Micro-
Tomography and Scanning Electron Microscopy. Micro-,
Macro- and Nano-mechanical analyses were also carried out.
A magnetic analysis was performed in order to assess the
behavior of these materials, highlighting their ability to be
magnetized at 37°C with an external magnetic field. Human
mesenchymal stem cell adhesion and viability were assessed
by means of Confocal Laser Scanning microscopy and
Alamar Blue assay, whilst cell differentiation was evaluated by
the measurement of ALP activity. Furthermore, the influence
of a time-dependent magnetic field on cell-laden constructs
was also studied. In conclusion, this work suggested these
materials as suitable candidates for bone regeneration.
ugo.damora@unina.itMaterials Science and Nanotechnology