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Materials Science and Nanotechnology | Volume 2
May 21-22, 2018 | New York, USA
International Conference on
Nanoscience & Technology
L
iposomes are used in ophthalmic preparations to increase
the corneal contact time and uptake of hydrophilic and
hydrophobic APIs of ocular preparations. Microfluidic chips
could be used as a continuous manufacturing process to
produce nanoparticles. The aim of this experiment was
to investigate the critical process and formulation factors
in the liposomal preparation of hydrocortisone through
microfluidic device. Three factors were investigated in this
study: flow rate ratio (FRR), drug concentration (DC) and
total lipid concentration (TLC). Liposomes particles size (PS),
polydispersity (PDI) and drug entrapment efficiency (EE %)
were selected as responses. Minitab software was used to
construct a central composite design (CCD) to analyse the
importance of these parameters. A microfluidic device (Y-
type, 2 inlets) was used to produce a liposomal formulation
for ophthalmic application. Hydrocortisone Acetate (HCA)
and sodium succinate (HSS) were used as a model drug to
investigate the effect of drug hydrophilicity on liposomes
size and encapsulation efficiency. Lecithin and cholesterol
were used as lipid. The obtained results show the FRR of
water/ alcohol was the significant factor for both drugs in
term of PS, PDI and (EE %). TLC and DC have an effect in
case of HCA but not in case of HSS. The Highest drug EE%
is 65 % for HSS and 29% for HCA. The design space for the
physical characteristics (CQA) of liposomes was determined
successfully with respect to the intended use.
e:
moussa.mahamatyaya@hotmail.frHydrocortisone acetate and sodium succinate liposomal preparations for ophthalmic application
using microfluidics
M M Yaya
University of Bradford, UK