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Allied J Med Res 2017
Volume 1 Issue 2
September 01-02, 2017 London, UK
3rd International Conference and Expo on
Herbal & Alternative Medicine
Herbal Medicine 2017
Drug development from natural resources:
an insectivorous plant, Drosera burmannii, is
a source of better medicine to combat breast
cancer by altering tumor-microenvironment
The routine conventional therapy can not differentiate
between the malignant and normal cells. Due
to this problem, purified chemical drug therapy i.e.,
Chemotherapy often manifests into harmful side effects
in patient’s body. Drug resistance, in some cases, is
also another major problem. Thus, it is still a challenge
for scientific community to develop new therapies
focusing on cancer cell and its microenvironment
including inflammation, while avoiding the detrimental
side effects of conventional therapies involving synthetic
drugs. We have explored various natural resources
including medicinal plants, algae and lichens for
their potent antioxidative and free radical scavenging
efficacies, among which eleven resources have shown
in vitro anticancer effects in various cancer cell lines by
inducing apoptosis and/or regulation of cell cycle, while
being nontoxic to the normal cells. For the first time,
Sundew plant, Drosera burmannii an insectivorous
plant have been investigated for in vitro anticancer and
anti-inflammatory activity. 70% methanolic extract of D.
burmannii (DBME) selectively inhibited the proliferation
of breast cancer (MCF-7) cells without affecting the
viability of other malignant and non-malignant cells.
DBME induced G2/M phase arrest and apoptosis in
MCF-7 cells by suppressing the expression of cyclin A1,
cyclin B1 and Cdk-1; and increasing the expression of
p53, Bax/Bcl-2 ratio leading to activation of caspases
and PARP degradation, hence, activating both the
pathways of apoptosis. DBME also down regulated
LPS-induced increased expression of iNOS, COX-
2 and TNF-α along with suppression of intracellular
ROS production which confirms the potential of DBME
as anti-inflammatory extract. DBME also showed
excellent ROS and RNS scavenging along with iron
chelation and DNA protection activity. GCMS and HPLC
analysis of DBME revealed the presence of several
bioactive phytocompunds. Hence, D. burmannii can be
considered as a useful source for the discovery of new
drug leads against breast cancer.
Biography
Nripendranath Mandal has completed his PhD in the year of 1990 from University
of Calcutta and Postdoctoral studies from MIT, NCSU and SLUHSC, USA since
1989-1996. He is the Professor in the Division of Molecular Medicine, Bose
Institute, a premier research institute founded by Sir J C Bose, Calcutta, India. He
has published 142 papers in reputed journals, patents from seven countries, book
chapters, News Media, etc., and serving as reviewer for various renowned journals.
He has been elected Fellow of SERS, Meerut, 2015 and FZS, Kolkata, 2014 and
also received various awards and recognition for his marvellous research output.
Nripendranath Mandal
Bose Institute, Kolkata, India
Nripendranath Mandal, Allied J Med Res 2017