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August 23-24, 2018 | London, UK
Hematology and Oncology
2 nd International Conference on
Journal of Hematology and Blood Disorder | Volume 2
A Report of Cytogenetic abnormalities Found In 246 Mexican patients clinically diagnosed with
Myelodysplastic Syndrome (MDS), given the importance of Cytogenetic results in calculating the Risk
Assessment proposed by the IPSS-R
Marcelo F Rosales
Mendel Laboratory, Mexico
Myelodysplastic syndromes (MDS) is a group of clonal
disorders characterized by progressive cytopenia’s and
dishematopoiesis. Anemia is frequently observed along with a
defect of protoporphyrin synthesis like ring sideroblastic which
are seen inpatientswithdeletion5q. Thedysplastic changes like
macrocytosis is the most commonly observed. In neutrophils
and eosinophils is also commonly found hip granulation. The
etiology of primary MDS is unknown, its general biological
characteristics include impaired hematopoiesis, which may be
accompanied by molecular, immunological and/or cytogenetic
abnormalities. These group of chromosomal abnormalities
considered as a prognostic factor within the MDS (very good,
good, intermediate, poor and very poor), being the most
recent the Revised International Prognostic Scoring System
(IPSS-R). This article gives a description of several cytogenetic
abnormalities found as evidence within 246 Mexican-mestizo
patients with a diagnosis of MDS. In each of the 246 cases, two
unstimulated cell cultures of bone marrow or peripheral blood
were set up, and the GTG banding technique was performed.
An analysis of twenty (20) metaphases were done on average
in each case, and chromosomes with a resolution of 300 to 500
bands. The nomenclature report was written sing an up to date
International System of Human Cytogenetics Nomenclature
(ISCN). Most of the findings of cytogenetic abnormalities in this
population with MDS are directly related to patient age, given
the 76.5% of the reports generated with abnormal karyotypes
belong to patients older than 50 years old. The chromosomal
abnormalities found in our study coincides with that reported in
the literature, which is del (5q), this abnormality was observed
in 28% (18 cases). Also, the abnormalities of chromosome 7
and 8 were observed by the same percentage as the literature
reports, being 12.5 % (8 cases). From the abnormalities found,
17% of them involved chromosome 11, including t(9;11).
Other abnormalities observed include additions, inversions,
translocations involving different chromosomes. Finally, there is
a correlation between the abnormalities found in our study and
the stratification of risk classification proposed by the IPSS-R.
Speaker Biography
Marcelo F Rosales completed his degree of specialist in diagnostic hematology by
laboratory in 2012 at the Institute of Hematopathology in Mexico City. He is director of
the Rosales laboratory founded in 1958 in Rio Bravo Tamaulipas Mexico He is currently
a main professor of Hematology courses in the northern area of Tamaulipas and is
a collaborator of the Leading Cytogenetic Laboratory in Mexico, Mendel Laboratory
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