hematology-2018-scientifictracks

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August 23-24, 2018 | London, UK

Hematology and Oncology

International Conference on

Journal of Hematology and Blood Disorder | Volume 2

SLE as a hematological problem & the Kozhikode criterion for diagnosis of SLE

Sasidharan P K

Government Medical College, India

LE can present with hematological manifestations alone

or along with musculoskeletal, skin or other system

involvement. In cases with hematological abnormalities as

the predominant or only manifestation, the diagnosis is often

delayedormissedat thetimeofpresentation, this isespeciallyso

if the index of clinical suspicion is low or if there is improper and

inadequate follow up. An observational study was conducted in

our institution with the purpose of estimating the proportion

of SLE with hematological manifestations as the initial

presentation of the disease. It was observed that 76.8% of the

patients had hematological manifestations at first presentation.

Thus hematological manifestations were found to be the most

common presenting manifestation of SLE in people of North

Kerala which is not given due importance in the ACR criteria for

diagnosing SLE. One of the common coexisting abnormalities

in patients with initial hematological presentation was

autoimmune hypothyroidism, which also is not included in the

ACR criteria. The most common hematological abnormalities

at presentation were ITP, autoimmune hemolysis and APLA.

In addition there was an inverse association of arthritis with

hematological manifestations. Thus it appears that SLE is more

of a Hematological disorder rather than a Rheumatologic

disorder. A significant number did not satisfy the ACR criteria

at the time of diagnosis but did so on follow up. The ACR

criteria are weak to diagnose such patients and therefore needs

revision. We have developed an alternative to ACR criteria as

“Kozhikode Criteria for SLE” which was validated in another

studyandwaspublished,boththesetheissueswillbepresented.

Speaker Biography

Sasidharan P K is an Emeritus Professor, Department of Family Medicine, Govt.Medical

College, Kozhikode. He was a Former Professor & Head, Department of Medicine &

Haematology, Government Medical College, Kozhikode. He also served as the President

Hypertension Society of India, Editorial Board Member Indian Journal of Hematology

and PhD research Guide for University of Calicut.