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academies
Microbiology: Current Research
Volume 2
International Conference on
Emerging Diseases, Outbreaks & Case Studies
&
16
th
Annual Meeting on
March 28-29, 2018 | Orlando, USA
Influenza
I
nfluenza-related pneumonia is an important complication
of influenza, and it has been suggested that excessive
inflammatory reactions, including “cytokine storm”, may
contribute to the mechanisms underlying severe pneumonia.
Human data andmousemodel which co-infectedwith influenza
virus and
Streptococcus pneumoniae
show increased severity
of illness caused by the elevation of cytokines/chemokines,
and mice with genetic knock-out of immune molecules such
as Toll-like receptor-related IRAK-M also show hyper-immune
responses and reduced survival following influenza virus
infection. Such findings suggest that innate immune responses
and excessive neutrophil activation might be related to severe
inflammatory changes in the lungs, and immune-modulatory
therapy, including macrolides, may thus be effective against
severe influenza-related pneumonia. In Japan, we have five
anti-influenza agents and can choose each agent dependent
on influenza and pneumonia severity. Among them, peramivir
can be administered by drip infusion, and used not only for the
most severe patients, but also for the ambulatory outpatients
who have some medical issues. The insurance system supports
early administration of them with antibiotics, and as a results,
we might be able to have very low influenza-related mortality
Today, ourmanagement style for influenza, includingvaccination
and infection control team activity, will be introduced.
Speaker Biography
Masafumi Seki has completed his graduation in Medicine from Nagasaki University,
with the specialties including Internal Medicine, Infectious Diseases, and Infection
Control. Later on, he has obtained his Post-graduation and started working at Osaka
University. Presently, he is working at the Tohoku Medical and Pharmaceutical
University, Sendai City, Japan.
seki@hosp.tohoku-mpu.ac.jpMasafumi Seki
Tohoku Medical and Pharmaceutical University, Japan
Mechanisms and characteristic management of influenza and its related
Pneumococcal pneumonia in Japan