9 / 12
allied
academies
Page 36
Notes:
Journal of Diabetology | Volume 3
May 16-17, 2019 | Prague, Czech Republic
Diabetes and Endocrinology
27
th
International Conference on
J Diabetol, Volume 3
Current trends and gaps in managing obesity and type 2 diabetes – Discovery of
targeted treatment modalities for effective management and prevention
Christina GY, Koh HS, Jessie Ngu SE, Nur Dania R, Chang YX
and
Ahmad Farouk M
Jeffery Cheah School of Medicine and Health Sciences, Malaysia
T
he prevalence of obesity continues toward an upward
soaring trend worldwide. Despite frontiers in innovative
treatment and management plans obesity is currently an
epidemic. The pathophysiology of chronic obesity naturally
provokes the onset of type 2 diabetes therefore, obesity is a
majorriskfactorfortype2diabetes.Bothobesityanddiabetes
rob patients of their quality of life and threatens catastrophic
complications.Duetothecomplexmultifactorialnatureofthe
pathophysiology of obesity and its complicationsmultilayered
treatment is required. Knowing accurately the interplay
of specific biomolecules during the early pathogenesis of
obesity and type 2 diabetes will shed light in developing
early diagnosis tests and more precise treatment plans.
We conducted a literature study of Medline, the Cochrane
Database of Systematic Reviews, and citation list of relevant
publications. Subject heading and key words used include
current trends of obesity and diabetes, current diagnostic
methods for diabetes, definition of obesity, treatment and
management of obesity/diabetes, early biomolecules in the
pathogenesis of pre-diabetes, biomolecules linking obesity
and diabetes, current issues and limitations in treating obesity
and diabetes. Candidate of early biomolecules for diagnosis
of pre-diabetes were extracted from evidences learnt from
integrated metabolomics, transcriptomics and proteomics
studies. Biomolecules were identified, mapped on the
pathogenesis pathway of pre-diabetes and selected based on
their merits in the early pathogenesis process. Subsequently,
a proposed future study protocol was developed to evaluate
our hypothesis: “Together with weight control management,
pharmacological treatment targeting on early biomolecules
in the pre- diabetes state will prevent the development of
type 2 diabetes in over weight and obese individuals”. An
early biomolecules array for pre-diabetes will be developed
and used as a tool in the proposed clinical study. The outcome
of this study will impact on lowering the prevalence of type 2
diabetes patients, complications of obesity and diabetes and
would overall eases the domestic and worldwide economic
burden.
e
:
christina.yap@monash.edu