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Journal of Diabetology | Volume 3
May 16-17, 2019 | Prague, Czech Republic
Diabetes and Endocrinology
27
th
International Conference on
J Diabetol, Volume 3
Association between HbA1C levels and pregnancy outcome in diabetic pregnancies
Adel Taha Abu Heija
Mutah University, Jordan
Objective:
To study the associationbetweenHbA1C levels and
maternal & perinatal outcome, in pregnancies complicated
with diabetes mellitus.
Method:
It is an observational retrospective study. In this
study we reviewed all singleton pregnant women with any
type of diabetes who gave birth in Sultan Qaboos University
Hospital, Muscat, Oman between (2013 - 2015). During the
study period, there were 9,358 deliveries, of whom 966
pregnancies complicated by diabetes mellitus (DM) 10.29%.
We excluded twin and triplet gestations complicated by DM
(N=19), so the study group comprised of 947 (10.1%). In this
study, HbA1C was performed in each trimester and results
were considered abnormally high when it exceeds 6%.
Results:
In this study,16% of women studied were aged under
25 years, 66% aged between 25-35 years and 18% aged more
than 35 years. Regarding body mass index (BMI) of the study
population, 64% had BMI. 29 kg/m2, 25% had BMI between
25-29 kg/m2 and 11% of women had BMI under 25 kg/m2.
It is shown that only 1.2% of women had type 1 DM, 8.2%
had pre-gestational diabetes mellitus (PGDM) and 90.6% had
gestational diabetes mellitus (GDM). Majority of women with
GDM, blood sugar was controlled with diet alone (71.5%)
and the rest were controlled by Insulin (19.1%). Macrosomia
was observed only in 0.48% of all deliveries during the study
period while in the study group this was observed in 4.7% of
women nearly 10 times. While caesarean delivery increased
from22% during the study period to 26.6% in the study group
(P<0.001). Cesarean section rate of 26.6% was significantly
correlated with mean HbA1C levels in 2
nd
and 3
rd
trimesters
(p<0.001). There were 9 stillbirth and 5 IUFDs, 7 stillbirths
and 4 IUFDs had HbA1C>8%. All neonatal complications have
positive correlation with HbA1C in 2
nd
and 3
rd
trimesters.
Conclusions:
Starting from a first-trimester, HbA1C level >6%,
there is associated with adverse pregnancy outcome.
e
:
abuheija2008@hotmail.com