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Archives of General Internal Medicine
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Volume 2
2
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Bosan Istifanus B, Arch Gen Intern Med 2018, Volume 2 | DOI: 10.4066/2591-7951-C5-014
ANAEMIA IN CHRONIC KIDNEY DISEASE IN
NORTH WEST NIGERIA
Bosan Istifanus B
Ahmadu Bello University, Nigeria
Introduction:
Anaemia isacommonextra renalmanifestationof chronickidney
disease (CKD). The anemia increases as the kidney disease progresses. It is
associated with increased cardiovascular morbidity and all cause mortality
in CKD. Effective treatment of anemia in CKD improves the quality of life and
significantly reduces mortality. It presents with normochromic, normocytic
and hypo proliferative picture. Generally thought to be due to failure of the
kidneys to produce the required erythropoietin but in some cases the serum
level of erythropoietin may be higher than non-anemic individuals. Disordered
iron homeostasis is a very important cause of anemia in CKD.
Method:
In a cross-sectional descriptive study of 91 subjects attending the
Nephrology clinic of a major teaching hospital in North West Nigeria, a pre-
tested questionnaire was administered for basic biodata and diagnosis of CKD
and the hemoglobin level, serum iron studies (ferritin and soluble transferrin
receptors) and serum erythropoietin were all evaluated.
Result:
Over 74 per cent (74.7%) males had anemia at hemoglobin <13.0gm/
dl while 62.5% of females had anemia at 12.0gm/dl. Mean serum ferritin level
was 70.58±46.44 ug/ml, soluble transferrin receptor was 22.9±49.7 ng/ml.
Serum erythropoietin was 12.49±33.47 iu/L.
Conclusion:
The males in our patients are more likely to be anemic than the
females. Iron deficiency is a very important cause of anemia in our patients
with CKD and relatively higher levels of serum erythropoietin suggests hypo
responsiveness to erythropoietin.
Bosan Istifanus B has completed his postgraduate fel-
lowship training with the West African College of Phy-
sicians in 1994. Presently, he is Associate Professor of
Medicine with the Ahmadu Bello University, Zaria and
Chief Consultant Physician/Nephrologist and Head
of Nephrology Unit at the Ahmadu Bello University
Teaching Hospital, Zaria. He has 31 publications cited
42 times. He was Secretary General of the Nigerian
Association of Nephrology.
ibosan2k2@yahoo.co.ukBIOGRAPHY