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S e p t e m b e r 2 0 - 2 1 , 2 0 1 8 | R o m e , I t a l y
Joint Event on
OF EXCELLENCE
IN INTERNATIONAL
MEETINGS
YEARS
Dermatology Congress 2018 & World Nephrology 2018 Archives of General Internal Medicine | ISSN: 2591-7951 | Volume 2
2nd WORLD NEPHROLOGY AND THERAPEUTICS CONGRESS
DERMATOLOGY AND TRICHOLOGY
&
International Congress on
Nianping Feng et al., Arch Gen Intern Med 2018, Volume 2 | DOI: 10.4066/2591-7951-C5-014
INVESTIGATION OF THE WORKING
MECHANISM AFTER TRANSDERMAL
ADMINISTRATION OF A TCM COMPOUND
PRESCRIPTION XZT BY A METABOLOMICS-
BASED SYSTEMATIC STRATEGY
Nianping Feng, Kai Zhang, Yongtai Zhang, Nana Li, Feng Xing,
Tao Yang, Jihui Zhao and Chenghai Liu
Shanghai University of Traditional Chinese Medicine, China
Traditional Chinese medicine (TCM) has a long history and rich experi-
ences in treating cirrhotic ascites and nowadays is widely applied in
clinical practice as a complementary and alternative approach. XZT, a tradi-
tional Chinese herbal cataplasm, has been shown to be effective in treating
cirrhosis-associated ascites in clinical practice. XZT composed of Dahuang
(Rheum palmatum L), Laifuzi (Raphanus sativus L), Gansui (Euphorbia kansui
TN Liou ex TP Wang), Chenxiang ( Aquilaria sinensis (Lour) Gilg), Dingxiang
(Eugenia caryophyllata Thunb.), Bingpian (Borneolum syntheticum) and Shex-
iang (artificial Moschus). In trying to uncover the working mechanism of such
combined system, we used a metabolomics-based systematic strategy to
trace the molecular basis as well as the pharmacokinetic behavior of XZT. Our
results revealed that the peak plasma concentrations and bio availabilities of
the active ingredients were significantly increased in rats with cirrhotic asci-
tes, thus proving the rationality of external XZT therapy. Metabolomics study
demonstrated that XZT mediated synergistically abnormalities of amino acid
metabolic pathways in cirrhotic rats. Biomarkers identified in the metabol-
ic profiling were validated through targeted quantitative analysis and by the
results from serum and urine. We found that regulation of L-arginine/nitric
oxide (NO) pathway was the most important mechanism of XZT to improve
the gastrointestinal motility of cirrhotic rats. This effect of XZT has been con-
firmed by the inhibition of inducible NO synthase and neuronal NO synthase
activities in the small intestine. This work gave a valuable insight into the
mechanism of XZT and provided an effective way to elucidate the mecha-
nisms of combined therapeutic systems.
Nianping Feng is currently full Professor and the
Director of the Department of Pharmaceutical Sci-
ences at Shanghai University of Traditional Chinese
Medicine. He received his PhD degree from China
Pharmaceutical University in June 1997 and was an
Assistant Research Professor at the same university
prior to joining the Shanghai University of Traditional
Chinese Medicine in Oct. 1998. He worked as a Senior
Scientist at Purdue University fromSept. 2012 to Sept.
2013. His research interests include novel drug deliv-
ery systems, pharmaceutical nanotechnologies and
TCM-based new drug development. He has published
more than 100 peer-reviewed articles and book chap-
ters and holds 11 patents.
BIOGRAPHY