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S e p t e m b e r 2 0 - 2 1 , 2 0 1 8 | R o m e , I t a l y
Joint Event on
OF EXCELLENCE
IN INTERNATIONAL
MEETINGS
YEARS
Dermatology Congress 2018 & World Nephrology 2018 Archives of General Internal Medicine | ISSN: 2591-7951 | Volume 2
2nd WORLD NEPHROLOGY AND THERAPEUTICS CONGRESS
DERMATOLOGY AND TRICHOLOGY
&
International Congress on
Mariana Ciocchini, Arch Gen Intern Med 2018, Volume 2 | DOI: 10.4066/2591-7951-C5-014
MONOCLONAL GAMMOPATHY OF RENAL
SIGNIFICANCE (MGRS): DIAGNOSTIC
CLUES
Mariana Ciocchini
Universidad de Buenos Aires, Argentina
Monoclonal gammopathy of renal significance (MGRS) is a recently
described haemato-nephrological meta-entity caused by monoclonal
immunoglobulins(Ig)orhumoralfactorssecretedbysmallB-cellclones.MGRS
can affect any nephronal area with a broad spectrum of histopathological
patterns which can coexist even in the same patients. Given that, MGRS can
clinically appear as any of the classical nephrological syndromes, from a
nephrotic syndrome to a polyuric state. Kidney injury mediated by monoclonal
Ig is mainly the result of its deposit in renal tissue, as in AL amyloidosis.
Monoclonal Ig can also have auto-antibody activity which is responsible for
a cluster of disorders related to the dysregulation of the alternative pathway
of complement, for example, atypical hemolytic uremic syndrome. The third
pathophysiological mechanism depends on humoral factors like in POEMS
syndrome’s nephropathy. Renal biopsy has a diagnostic and a prognostic role,
both with therapeutic implications. Renal biopsy is imperative to achieve a
precise MGRS diagnosis. MGRS as a meta-entity is a fascinating challenge
which is changing nephrological paradigms.
Mariana Ciocchini is an MD (Universidad de La Plata)
and Nephrologist (Universidad de Buenos Aires). Her
research focuses on monoclonal gammopathy of re-
nal significance and she has published papers about
this subject in a reputed journal. She is a Member of
the Glomerulopathy Council, ANBA, Argentinian Soci-
ety of Nephrology being one of the co-authors of the
book “Glomerular Diseases” recently published by this
group.
BIOGRAPHY