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S e p t e m b e r 2 0 - 2 1 , 2 0 1 8 | R o m e , I t a l y
Joint Event on
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Dermatology Congress 2018 & World Nephrology 2018
Archives of General Internal Medicine
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ISSN: 2591-7951
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Volume 2
2
nd
WORLD NEPHROLOGY AND THERAPEUTICS CONGRESS
DERMATOLOGY AND TRICHOLOGY
&
International Congress on
Arch Gen Intern Med 2018, Volume 2 | DOI: 10.4066/2591-7951-C5-015
DIRECT EVIDENCE OF VIRAL INFECTION AND MITOCHONDRIAL
ALTERATIONS IN THE BRAIN OF FETUSES AT HIGH RISK FOR
SCHIZOPHRENIA
Segundo Mesa Castillo
Psychiatric Hospital of Havana, Cuba
Introduction:
There is increasing evidences that favor the prenatal beginning of schizophrenia. These evidences point towards
intra-uterine environmental factors that act specifically during the second pregnancy trimester producing a direct damage of the
brain of the fetus. The current available technology doesn’t allow observing what is happening at cellular level since the human
brain is not exposed to a direct analysis in that stage of the life in subjects at high risk of developing schizophrenia.
Methods:
In 1977, we began a direct electron microscopic research of the brain of fetuses at high risk from schizophrenic
mothers in order to finding differences at cellular level in relation to controls.
Results:
In these studies we have observed within the nuclei of neurons the presence of complete and incomplete viral particles
that reacted in positive form with antibodies to herpes simplex hominis type I [HSV1] virus, and mitochondria alterations.
Conclusion:
The importance of these findings can have practical applications in the prevention of the illness keeping in mind its direct
relation to the aetiology and physiopathology of schizophrenia. A study of the gametes or the amniotic fluid cells in women at risk
of having a schizophrenic offspring is considered. Of being observed the same alterations that those observed previously in the
cells of the brain of the studied foetuses, it would intend to these women in risk of having a schizophrenia descendant, previous
information of the results, the voluntary medical interruption of the pregnancy or an early anti HSV1 viral treatment as preventive
measure of the later development of the illness.