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Note:

S e p t e m b e r 2 0 - 2 1 , 2 0 1 8 | R o m e , I t a l y

Joint Event on

OF EXCELLENCE

IN INTERNATIONAL

MEETINGS

YEARS

Dermatology Congress 2018 & World Nephrology 2018

Archives of General Internal Medicine

ISSN: 2591-7951

Volume 2

WORLD NEPHROLOGY AND THERAPEUTICS CONGRESS

DERMATOLOGY AND TRICHOLOGY

International Congress on

Arch Gen Intern Med 2018, Volume 2 | DOI: 10.4066/2591-7951-C5-015

THE PREVENTIVE EFFECT OF DATE PALM (

PHOENIX DACTYLIFERA

) SEED

AND FRUIT HYDROALCOHOLIC EXTRACTS ON CARRAGEENAN-INDUCED

INFLAMMATION IN MALE RAT’S HIND PAW

Siavash Azarbani

Ahvaz University Medical Science, Iran

Background & Objective:

The side effects of NSAIDS drugs, have caused increasing interest of scientists in herbal medicines as

alternative treatment. In this study, the effect of anti-inflammatory of seed and fruit of date palmhydroalcoholic extracts, due to having

antioxidants, was studied.

Materials & Methods:

In this study, the extracts of date palm seed and fruit were prepared by maceration method in 70% alcohol.

80 male rats Wistar, divided into 10 groups of eight in each, four groups received different doses (100, 200, 400 and 600 mg/kg)

of seed extract and four other groups different doses (100, 200, 400 and 600 mg/kg) of fruits extract of the palm, and the positive

control aspirin (300mg/kg) and the negative control group saline (5ml/kg) via injection intraperitoneally. Half an hour later all

animals received 100 µl of 1% carrageenan into the rats’ hind paw subcutaneous. The changes in rats paw edema was measured

by plethysmometer every hour for five hours.

Results:

The effect of all the doses of date palm seed extract on edema were less than aspirin (P<0.05). But there was no

significant difference between the group that received 400 and 600 mg/kg date palm fruit extract when compared with aspirin

group. The dose 400 mg/kg of fruit extract showed the most anti-inflammatory effect and it was assigned as the best dose.

Conclusion:

It is likely that with further studies on different model of animals and on human model the palm fruit extract could

be used for pain treatment.