2 / 9
allied
academies
Page 41
Notes:
September 05-06, 2019 | London, UK
7
th
International Conference on
2
nd
International Conference on
Otolaryngology: ENT Surgery
Dental Health and Oral Hygiene
Joint Event
&
Salivary Metabolomics and Oral Cancer
Gokul Sridharan
YMT Dental College and Hospital, India
C
ancers of the oral cavity especially oral squamous cell
carcinoma is a common malignancy associated with
significant morbidity and mortality. Oral squamous cell
carcinoma is a multifactorial disease characterized by a
complex interplay of environmental factors and molecular
alterations resulting in unhindered cell proliferation.
Despite diagnostic and therapeutic advances, the disease
remains a challenge for medical professionals with poor
five-year survival rate. Lack of awareness of the precursor
lesions of oral cancer, delayed diagnosis and absence of
adequate screening and diagnostic modalities are some
of the reasons for the poor survival rate of OSCC. Over
time, the technological advancements have enabled us to
unravel some of the intricate details of oral carcinogenesis.
“Omics” technology encompassing genomics, proteomics,
transcriptomics and metabolomics are increasingly being
used in cancer diagnostics. Metabolomics is the study of
metabolome which includes a repertoire of small molecules
present in cells, tissues, organs and biological fluids. The
metabolome is considered as the final downstream product
and hence closest to the phenotypic nature of the cell.
Analyzing the metabolomic profile could aid in identification
of tumor biomarkers in OSCC. Saliva as a diagnostic tool has
gained wide acceptance owing to its non-invasive nature,
ease of collection and the availability of sensitive and specific
techniques for identification of minor quantities of the
metabolite. This presentation provides an overview of the
clinical significance of salivary metabolomics highlighting the
importance of salivary based tumor biomarkers in oral cancer.
Speaker Biography
Gokul Sridharan is currently working as an associate professor in the
department of oral pathology and microbiology at YMT Dental College and
Hospital, Navi Mumbai. He has obtained his Doctor of Philosophy (PhD)
for his work titled “Salivary and serum metabolomics in oral leukoplakia
and oral squamous cell carcinoma” and his field of interest includes oral
pre-cancer, oral cancer, salivary diagnostics, metabolomics and oxidative
stress. He has several scientific publications and actively contributes as a
peer reviewer to numerous journals. He is an active member of editorial
board of several journals of repute. Dr. Gokul Sridharan has undergone
training and is a qualified diploma holder in medial law and ethics and is
also certified in tobacco cessation and control.
e:
drgokuls@gmail.comJ Clin Dentistry Oral Health
Volume 3
Journal of Clinical Dentistry and Oral Health | Volume 3