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Note:
alliedacademies Joint Event on
Dental Congress 2018 & World Dermatology 2018 Archives of General Internal Medicine | ISSN: 2591-7951 | Volume 2
WORLD DERMATOLOGY AND COSMETOLOGY CONGRESS
DENTISTRY AND ORAL HEALTH
&
International Conference on
Michel Laurence, Arch Gen Intern Med 2018, Volume 2 | DOI: 10.4066/2591-7951-C2-005
NOVELTIES IN SKIN AGING
Michel Laurence
Inserm, France
To identify the role of dermal fibroblasts in age-related scarring defects,
we have described in a recently published study the differences between
human dermal fibroblasts from young and old donors in terms of age,
phenotypic characteristics, including senescence, and functional abilities:
activation in myofibroblasts, stress response, migration and contraction.
We also investigated the differentiation capabilities of dermal fibroblasts in
adipocytes according to the age of the donors (young slice and aged slice). We
characterized these fibroblasts in terms of membrane markers and adipocyte
differentiation capabilities and compared them to mesenchymal stem cells.
We then studied the effect of age on these two parameters: differentiation
capacityandexpressionofmembranemarkersanddemonstratedanalteration
of these two points with age. Recent data have been collected to establish
comparison of proteomic and secretomic profiling of young and aged dermal
fibroblasts. Numerous proteins have been identified and are currently studied
for their function in aging by KO down-regulation or surexpression. Moreover,
our results brought evidence of the involvement of predominant combined
molecular signaling pathway in subjects with early androgenetic alopecia
compared to normal volunteers. This set of data suggests a gene profiling of
premature skin aging in human beings.
Michel Laurence is specialized in Dermatology and
Pharmacology, she is responsible for research group
in the Skin Research Center, Inserm Unit, at Paris
Saint-Louis Hospital. She works in the Research Team
at the Skin Research Institute conducted by Professor
Martine Bagot, Head of the Dermatology department
at Saint-Louis Hospital and Dr Armand Bensussan, Di-
rector of Inserm Unit. She also worked at the Inserm
Unit on a fundamental research project studying the
mechanism of signaling pathways involved in cuta-
neous cell resistance to treatment, with a focus on
drug-induced apoptosis. Several partnerships have
been also established with cosmetic laboratories to
provide experimental designs in vitro and in vivo in
human beings. Her work has yielded 67 articles and
three patents including new cosmetic dressings. She
is involved as external expert in several national and
international academic institutions.
BIOGRAPHY