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S e p t e m b e r 0 3 - 0 4 , 2 0 1 8 | B a n g k o k , T h a i l a n d
allied
academies
Joint Event on
Dental Congress 2018 & World Dermatology 2018
Archives of General Internal Medicine
|
ISSN: 2591-7951
|
Volume 2
WORLD DERMATOLOGY AND COSMETOLOGY CONGRESS
DENTISTRY AND ORAL HEALTH
&
International Conference on
Foia Georgeta Liliana et al., Arch Gen Intern Med 2018, Volume 2 | DOI: 10.4066/2591-7951-C2-006
CONTRIBUTIONS TO THE ANALYSIS OF THE
OXIDATIVE STATUS DURING PERIODONTAL
IMPAIRMENT
Foia Georgeta Liliana, Goriuc Ancuța, Surdu Amelia
and
Hurjui Loredana
Grigore T Popa University of Medicine and Pharmacy, Romania
Introduction:
Periodontal disease represents chronic inflammatory disorder
induced by products released from the dental plaque and host immune-
inflammatory response. Several mechanisms have been proposed to explain
the periodontal compromise, including a complex range of factors such as
those derived from immune response, direct bacterial influence, host system,
some metabolic harmful species such as reactive oxygen species being also
recognized as having significant impact.
Aim:
The aimof the study is to analysis themyeloperoxidase (MPO) in gingival
crevicular fluid (GCF) as a marker of oxidative stress in periodontal disease
in patients affected by periodontal oral territories alterations, compared to
clinically healthy subjects, associated with evaluation of clinical indicators of
the disease.
Materials & Methods:
For this study, we selected 42 patients, 22 men and
20 women subsequently divided into three groups after assessing clinical
indicators of periodontal impairment: patients with chronic periodontitis
(n=6), patients with aggressive periodontitis (n=11) and the control group
represented by periodontal unaffected individuals (n=15). From each patient
GCF samples were collected using special paper strips of paper, followed by
their discharge in phosphate buffer, centrifuged and analyzed for marker of
oxidative stress through immune-enzymatic technique (ELISA).
Results:
Analysis of MPO in GCF recorded statistically significant differences
between the two groups of patients with chronic and aggressive periodontal
disease respectively, compared with controls. Moreover, it has been observed
a strong correlation between bleeding index and gingival fluid MPO value
in subjects with periodontal alterations, which demonstrates that reactive
species are important mediators of inflammatory periodontal damage.
Conclusions:
Oxidative stress is an important factor in the development
of periodontal breakdown and this can be evidenced through MPO, no
statistically significant differences between groups of patients with
aggressive periodontitis and those with chronic periodontitis being though
observed.
Foia Georgeta Liliana has completed her PhD at Grig-
ore T Popa University of Medicine and Pharmacy,
Iași, Romania. She is a Professor at Grigore T Popa
University of Medicine and Pharmacy, Romania. She
has over 100 publications that have been cited over
90 times, and her publication H-index is eight and has
been serving as an Editorial Board Member of reputed
journals.
lilifoia@yahoo.co.ukBIOGRAPHY